DrVirgo
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Hemoglobin curve!
See pic.
Attached Files:
3-2 17.JPG (22 KB, 153 downloads)
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| DrVirgo
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Is it C???
Please explain changes in Hgb curve at acute and long term high altitude and also exercise associated with those!
thanks> 
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| drkirti79
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Shifting of curve to right by C - Co2 ,A -Acid (pH) D- 2,3 DPG ,E-Exercise T - Temp. So it shud be C
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| robin082006
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C, shift to the right
High Altitude causesthe curve shift to the right
Excercise--> increase in H+---> shift to the right
Both---> increased shift to the right.
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| DrVirgo
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Exercise--> increase H+ because lactic acid from muscles?
robin082006 wrote:
C, shift to the right
High Altitude causesthe curve shift to the right
Excercise--> increase in H+---> shift to the right
Both---> increased shift to the right.
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| Cedrick
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thanks for the simple but yet very complete answer ciberclassmates
this is "was" one difficult concept that has been cleared thank to you
YES.!
C
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| cd
Forum Elite
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Can any one ans y cant be a D.
thanks
cd
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| babydoc4usmle
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don't you think that to shift curve to the right @ high altitude it has to bew few days at least?
first it goes to the left (nobody thinks otherwise, right?)
during excersie there will be shif to the right due to exercise, but will it outweight decrease in PO2? hmmmm.....
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| babydoc4usmle
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i just did a search and i found that in high altitude during training ODC can be shifter to the left OR to the right and it depends on how high it is (altitude), how traind individual is, diffusion capacity and other things
i don't think they would put a Q like that on the exam....i hope so
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| Clozapine
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Babydoc, I thought the same way too ... I thought the P50 decreases in high altitude and then 2,3 BPG adjusts it and shift the curve to right...but Ganong says exercise has been reported to produce an increase in 2,3-BPG within 60 minutes(although the rise may not occur in trained athletes).
The P50 is also increased during exercise, because the temperature rises in active tissues and CO2 and metabolites accumulate, lowering the pH. In addition, much more O2 is removed from each unit of blood flowing through active tissues because the tissues' PO2 declines.
Finally, at low PO2 values, the oxygen–hemoglobin dissociation curve is steep, and large amounts of O2 are liberated per unit drop in PO2. In high altitude, the rise in 2,3 BPG is secondary to the rise in blood pH, and it doesn`t take days.
So, to sum up, physical exercise in high altitude, the curve will shift to right and will be steeper.
I`m sure it`s in kaplan physio and I guess, it`s the hematocrit that takes days.
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| sprint123
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Hi..I thought of a wierd explanation..Please correct me if I am wrong..
High altitudes causes respirqatory alkalosis..Increased ph...Shift to the left...Exercise...Production of Co2 is balanced by hyperventilatrion and hence co2 levels doesn't change much...Am I missing something here???
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