DrVirgo
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14. Cells froma pancreatic carcinoma express very small amounts of Class I MHC and are resistant to recognition and killing by CD8+ T lymphocytes isolated from the host individual. Substantial tumor cell lysis is observed when these cells are cultured in the presence of a mixed leukocyte population isolated from the peripheral blood of a normal (cancer-free) individual. Which of the following leukocytyes in the blood of the normal individual are most likely responsible for the in vitro lysis of the tumor cells?
A. B-lymphocyte effector (plasma) cells
B. CD4+ T cells
C. CD8+ T cells
D. Eosinophils
E. Macrophages
F. Natural killer cells
G. Neutrophils
???C/F???
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| robin082006
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F
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| DrVirgo
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Thanks. 
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| Cedrick
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I had C
Change to F
Thank you
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| waqastariq
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its NK cells ...sudden substantial lysis is through NK cells and see its written.....only a small number of cells have MHC I so automatically rule out CD8+
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| vamsi2004
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why is it not E macrophages??
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| study_ing
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in immunity vs tumor cells, macrophages are not imp. intracellular ags--> think abt t lymphos and NK cells. macrophages themselves, need t cell activation to deal with the organisms sitting within thme!!
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| klimt
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Can anyone explain why not C? MHC I is present on all nucleated cells and it's associated with LT CD8+.
LT CD 8+ kill tumor/virus/graft cells. So, why not C?
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| mohelgamal
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dear klimt
the question stem says the tumor cells don't express mhc1 w
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| shabree
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F-
The answer is NK cells.
NK Killer cells are :
NOT thymus depepndent.
NOT MHC restricted
No memory
Would work if there are no MHC-1 receptor.
In This case , the tumor cells don't express mhc1 and so the answer is NK cells.
Please REMEMBER:
cytotoxic T cells act on tumor cells that have " altered self/ MHC calss 1 receptor
Hope this helps..
Love and wishes
Dr Shabree
Sabarinath Radhakrishnan
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| ManuNastai
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agree F
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| drfax
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F. Nk cells , at the stem of the Q the CD8+ automatically been roled out, so just u have to choose NK cells.
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| yasmeen
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F NO MHC RESTRICTION
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| ashfaque
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F
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