asmi
Forum Hero
Topics: 1043
Posts: 4,609
|
A kidney biopsy specimen taken from a patient with acute glomerulonephritis and stained with fluorescein-conjugated anti-human IgG antibody would probably show
A. no fluorescence.
B. uniform fluorescence of the glomerular basement membrane.
C. patchy, irregular fluorescence of the glomerular basement membrane
D. fluorescent B cells.
E. fluorescent macrophages
|
| meg
Forum Guru
Topics: 62
Posts: 806
|
C (post streptococcal) I think poststreptococcal is the commonest unless the question mentions anything about others. (hypocomplement- Membrano, hemoptysis- good pasture etc)
http://www.merck.com/mrkshared/mmanual/tables/231... a nice listing of findings
|
|
|
I think the most common is bergers disease
|
| asmi
Forum Hero
Topics: 1043
Posts: 4,609
|
Thx meg! 
|
| meg
Forum Guru
Topics: 62
Posts: 806
|
I am not sure which is the commonest glomerulnephritis, but C is probably right because except Good PAstures (which is antibasement membrane),all other immunecomplexes will be irregular.
|
|
|
but bergers wont show any floresence with IgG. So I go with A
|
| mjl1717
Forum Hero
Topics: 960
Posts: 5,468
|
Id say meg answered this.
This off the subject, but Ive seen a semi colorful pic displaying linear immunofluorescence-and that was suppose to be Goodpastures Disease.
___________________
Smell the coffee! "Is That an Osler move??"
|
| meg
Forum Guru
Topics: 62
Posts: 806
|
In Good pasture, we see linear because it is Anti-Basement membrane Ab, hence entire BM will immunoflourescence, in all other immunecomplex conditions, it will be patchy because the antigen is not the BM
|
| Faraz
|
The answer is A, remember the acute glomerulonephritis is most commonlly secondary to group A B hemolytic strep, so u see immune complexes on subepithelial side of BM, and since its an acute condition there's no time for reactive BM thickening leading to the term "subepithelial humps"...so you'll find immunoflorescent patches on flourstain.
|
| Faraz
|
oops i mean ans is C , Mistake in the last post.
|
| meg
Forum Guru
Topics: 62
Posts: 806
|
which is the commonest acute glomerulonephritis, is it IgA (Bergers- post upper respiratory tract infection~ Henoch Schonlein) or poststrep?
In India, I always thought it was post strep.
Here, somewhere I found that it is IgA...
what is the commonest here? is IgA correct?
|
| Idiopathic
Forum Guru
Topics: 19
Posts: 641
|
IgA nephropathy post URI
|
| asmi
Forum Hero
Topics: 1043
Posts: 4,609
|
yes meg,
Here its IgA which is more common than poststrep...In our country(India) its poststrep.
|
|
| |
| | | | | | | | | | | | | |
Similar forum topics