DrVirgo
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13. A 62 year old man is admitted to the hospital for treatment of psychotic episode, for which he is given haloperidol. He is also being treated for electrolyte abnormalities, and is receiving salsalate therapy for treatment of osteoarthritis. While in the hospital, he complains of dizziness and tinnitus, and over the past 12-24 hours, he begins experiencing agitation, tachycardia, diaphoresis, and nausea with two episodes of vomiting. His signs and symptoms are most likely related to a drug interaction with one of his medications and which of the following?
A. Ammonium Chloride
B. Calcium carbonate
C. Multivitamin
D. Sodium bicarbonate
E. Sodium lactate
Explain. 
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| reet
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A. Amm chloride
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| Ivil
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C Multivitamin.. salsalate increases the bioavailability leading to hypervitaminosis
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| DrVirgo
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The answer is A.
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| robin082006
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A
Ammonium chloride acidizes urine, resulting in decrease in haloperidol excretion--> intoxication
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| Diego Casali
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A
Ammonium chloride acidifies urine, leading to a decrease in aspirin excretion.
robin082006, this is a description of salycilate intoxication, not haloperidol intoxication!
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| mjl1717
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Good catch Diego! !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
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| mjl1717
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For Haldol intoxication Biperiden and Lorazepam could be given. Repeated doses of physostigmine could be given cautiously, since it can increase the chance of seizure.
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