alpha12
Forum Senior
Topics: 6
Posts: 70
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Hi, all!
Can anyone explain this to me: the difference between:
-Tetanus, as due to continous cycling of cross-bridges, from increasing free intracellular calcium
-and Tetany, as due to hypocalcemia
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| dr_sarim
Forum Senior
Topics: 16
Posts: 75
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tetany :
when the concentration of calcium ions (Ca++) in extracellular fluids such as plasma falls below normal. The nervous system becomes increasingly excitable, and nerves discharge spontaneously, sending impulses to skeletal muscles and causing spasmodic contractions ( remember that skeletal muscle contraction does not depend on extracelluar Ca but depends on Ca derived from sarcoplasmic reticulum released as a result of action potential generated by a stimulus to nervous system---hypocalcemia in this case)
tetanus :
the spores contain toxin called tetanospasmin that enters the CNS and blocks the release of GABA/Glycine which regulate the excitatory neurons ( Ach releasers )...this regulatory control is lost and the excitatory neurons release Ach unopposed at the neuromuscular junctions generating action potentials...thus muscle spasm
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| alpha12
Forum Senior
Topics: 6
Posts: 70
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Thanks, Dr_Sarim, for your explanation!
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| sridevi
Forum Newbie
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 ya, thats really clear explanation
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| MRMAVERICK
Forum Guru
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