| Author | 6 Posts |
nadiabarati
|
A patient presents because he has been weak and falling down frequently. During the interview, you note that he irritable. On P/E, his skin is pale, his tarsal plates are pale, and he has a loss of vibration sense over his legs and trunk. His legs show a symmetric weakness with decreased DTRs. The leading theory for the pathophysiology of this disorder relates to which of the following?
A. Anomalous insertion of even-chain fatty acids into membrane lipids
B. Anomalous insertion of odd-chain fatty acids into membrane lipids
C. Increased vitamin A intake
D. Lack of methylmalonyl CoA
E. Lack of propionyl CoA
|
| Ivil
Forum Senior
Topics: 8
Posts: 169
|
D
___________________
Even if you are on the right track, you will get run over if you just sit there...KEEP RUNNING
|
| robin082006
Forum Hero
Topics: 471
Posts: 5,125
|
B
Subacute combined degeneration: ataxia, loss of vibration and proprioration, leg weaknesses. Cause is B12 dificiency.
A. Anomalous insertion of even-chain fatty acids into membrane lipids : not relevant
B. Anomalous insertion of odd-chain fatty acids into membrane lipids: possible
C. Increased vitamin A intake: not relevant
D. Lack of methylmalonyl CoA: redundant in b12 deficiency because B12 is cofactor for methylmalonyl CoA mutase--->methylmalonic aciduria
E. Lack of propionyl CoA: redundant in b12 deficiency (second subtract in propionic pathway)
___________________
The Key to Succeed is Patience.
|
| reet
Forum Fanatic
Topics: 152
Posts: 1,411
|
B
___________________
Live as u were to die tommorow. Learn as if u were to live forever.
|
| raves
Forum Elite
Topics: 21
Posts: 218
|
b 
___________________
'NISCHAY KAR APNI JEET KARO'
|
| tolito
Forum Fanatic
Topics: 119
Posts: 2,164
|
good question. indeed there should be increased levels of methylmalonyl co a in b12 def. nice distractor.
___________________
It has been a looooong hard journey but I am inches away from my destination...
|
|
| |
| | | | | | |
You don't have permission to post.
|
