unique1
InGodITrust
Topics: 19
Posts: 1,442
| | 04/10/07 - 02:59 PM
| #1176 |
A
B
B
D
E
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I can't change the direction of the wind, but I can adjust my sails to always reach my destination.
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| seems
Forum Elite
Topics: 7
Posts: 282
| | 04/10/07 - 03:44 PM
| #1177 |
1: A
2:B
3:B
4:A or B, am confused
5:dunt know
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| ShweHope99.9998
Forum Fanatic
Topics: 12
Posts: 2,686
| | 04/10/07 - 10:52 PM
| #1178 |
A, B ? , C ? , D , E 
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| mytime
Go Marching in!
Topics: 40
Posts: 3,177
| | 04/10/07 - 11:26 PM
| #1179 |
I THINK I'VE DONE THESE. tHANKS THOUGH!
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| Lily2008
Forum Junior
Topics: 2
Posts: 85
| | 04/11/07 - 08:21 PM
| #1180 |
Thanks NNL for posting all those great Qs:
The answes for this group: A B D B A
Is Duke’s C adenocarcinoma of the colon=HNPCC?
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Lily
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| new_n_lost
Forum Hero
Topics: 663
Posts: 6,107
| | 04/12/07 - 06:52 AM
| #1181 |
Mutations in which of the following genes when inherited in the germline are least likely to be associated with the development of breast cancer?
A. ATM gene
B. bcl-2 gene
C. BRCA 1 gene
D. BRCA 2 gene
E. p53 gene
BRCA 1 & BRCA 2 cause early breast cancer (dominant inheritance). ATM gene causes breast cancer ��" DNA repair disorder (recessive inheritance). P53 mutations are found in ~60% of all human cancer types including breast. Note Li-Frumeni syndrome ��" vulnerable to a wide range of cancers, 50% likelihood of Ca by age 30 & 90% by age 65. The precise function of p53 is unknown ��" may act as DNA policeman to prevent transcription & replication of unstable DNA.
Bcl-2 is involved in the control of apoptosis (programmed cell death) & prevents the p53 mediated destruction of cells with damaged DNA. It also may prevent the death of cells severely damaged by chemotherapy, & mediates drug resistance & contributes to neoplasia by this mechanism rather than promoting aberrant cell growth. It was first identified because of an association with follicular lymphoma.
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| new_n_lost
Forum Hero
Topics: 663
Posts: 6,107
| | 04/12/07 - 06:54 AM
| #1182 |
Which of the following is most suggestive of a mitochondrial DNA defect as the cause of a genetic disease?
A.Autosomal pattern of transmission
B.Maternal pattern of transmission
C.The finding of a cardiomyopathy
D.A change in the mitochondrial DNA sequence
E.The presence of somatic mosiacism
Maternal pattern of transmission
Mitochondrial inheritance
2 distinctive features.
- matrilineal inheritance.
both sexes affected but transmission only by females as mitochondria are only maternally derived. - hetroplasmy.
the presence of both normal & mutation carrying mitochondrial DNA in a cell ��" explains wide phenotypic variation between affected individuals in a family.
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| new_n_lost
Forum Hero
Topics: 663
Posts: 6,107
| | 04/12/07 - 06:55 AM
| #1183 |
Although type 2 diabetes is strongly inherited, the nature of the genetic defect remains unknown in most cases. In those cases where the responsible mutation has been identified, it most frequently involves the gene encoding which one of the following?
A) Insulin
B) Insulin Receptor
C) Glucose transporter
D) Glucokinase
E) Glycogen Synthetase
The Correct Answer is D
The glycolytic enzyme glucokinase plays an important role in the regulation of insulin secretion and recent studies have shown that mutations in the human glucokinase gene are a common cause of an autosomal dominant form of non-insulin-dependent (type 2) diabetes mellitus (NIDDM) that has an onset often during childhood.
___________________
FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| new_n_lost
Forum Hero
Topics: 663
Posts: 6,107
| | 04/12/07 - 06:56 AM
| #1184 |
Which of the following most specifically describes the use of linkage analysis in the search for a disease specific gene in a family?
A.The correlation of a DNA polymorphism with a family specific mutation
B.The finding of an association of a DNA polymorphism with the clinical phenotype
C.The drawing of a pedigree & to find who is normal & who is affected
D.To access a large pedigree & be able to obtain DNA from most of the family members
E.The drawing of a pedigree & to exclude the potential of non-paternity
The Correct Answer is B
Linkage analysis methods all rest on the biological phenomenon of recombination of homologous chromosomes. During meiosis homologous chromosomes pair up and exchange material. The probability of a recombination event occurring between loci far apart on a single chromosome is larger than for loci closer together. Hence, alleles at loci near each other are generally inherited (or co-segregate) together, making it possible to follow transmission from generation to generation at unknown loci by using alleles at neighbouring loci (i.e. the neighbouring locus alleles act as surrogates for the presence of alleles at other loci).
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| new_n_lost
Forum Hero
Topics: 663
Posts: 6,107
| | 04/12/07 - 06:56 AM
| #1185 |
A 45 year old man has Duke’s C adenocarcinoma of the colon. There is a strong family history of colon cancer in the absence of polyps. What is the most likely genetic basis?
A. Mismatch repair genes
B. Ras
C. Deletion in colon cancer
D. P glycoprotein gene
E. APC gene
The Correct Answer is A
History is most consistent with HNPCC
HNPCC is linked to mutations caused by microsatellite instability in several mismatch repair genes, notably hMSH2 & hMLH1. As a result, there is defect repair of DNA mismatches with abnormal cell growth & tumour development. The majority of these mutations are inactivating insertions or deletions.
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| Lily2008
Forum Junior
Topics: 2
Posts: 85
| | 04/12/07 - 07:07 AM
| #1186 |
Thanks NNL
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Lily
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| unique1
InGodITrust
Topics: 19
Posts: 1,442
| | 04/12/07 - 08:05 AM
| #1187 |
 NnL,
Regarding the fist q , if the mutation of Bcl2 gene is in the form of inactivation , then it will be least likely to produce cancer but what if the mutation is in the form of over expression of BCl2 gene ?
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I can't change the direction of the wind, but I can adjust my sails to always reach my destination.
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| ShweHope99.9998
Forum Fanatic
Topics: 12
Posts: 2,686
| | 04/12/07 - 09:48 AM
| #1188 |
Thanks NnL .
If do not mind like to do Q even have not read well yet.
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| new_n_lost
Forum Hero
Topics: 663
Posts: 6,107
| | 04/12/07 - 06:52 PM
| #1189 |
U.............. Still has least affilliation with Breast Cancer
___________________
FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| unique1
InGodITrust
Topics: 19
Posts: 1,442
| | 04/27/07 - 05:31 PM
| #1190 |
Any new questions guys ??????!!!!!!!! 
___________________
I can't change the direction of the wind, but I can adjust my sails to always reach my destination.
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| Novak75
Forum Senior
Topics: 3
Posts: 402
| | 05/28/07 - 12:44 AM
| #1191 |
Hi guys!, here are some questions from q bank, hope you haven't read them before, there from immuno: I had trouble with the copy and paste, so they are written centrally, hope is ok..
1.- A 7-month-old child is hospitalized for a yeast infection that does not respond<?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" />
to therapy. The patient has a history of multiple, acute pyogenic infections.
Physical examination reveals that the spleen and lymph nodes are
not palpable. A differential WBC count shows 95% neutrophils, 1% lymphocytes,
and 4% monocytes. A bone
marrow biopsy contains no plasma cells or lymphocytes. A chest x-ray reveals
the absence of a thymic shadow.
Tonsils are absent. These findings are most consistent with
A. Bloom's syndrome
B. chronic granulomatous disease
C. severe combined immunodeficiency
D. Waldenström's macroglobulinemia
E. Wiskott-Aldrich syndrome
2.- A researcher develops a specific antibody to the complement component C3b. Assume that
intravenous administration of the antibody prevents the biological effects of C3b. Administration
of the antibody would be expected to interfere with which of the following biological functions?
A. Decreased appetite
B. Fever
C. Increased collagen synthesis by fibroblasts
D. Increased leukocyte adherence to endothelium
E. Opsonization to facilitate phagocytosis
3.-
A 24-year-old man presents with complaints of itching on his arms and face. Physical examination reveals
well-circumscribed wheals with raised, erythematous borders and blanched centers. Which form of[/font">
[font="Times New Roman"]hypersensitivity is this patient probably exhibiting?
A. Acute serum sickness (Type III)
B. Antibody-dependent cell-mediated cytotoxicity (Type II)
C. Anti-receptor antibodies (Type II)
D. Delayed type hypersensitivity (Type IV)
E. Immediate type hypersensitivity (Type I)
4.-
A 45-year-old homeless man has a chronic cough, a cavitary lesion of the lung, and is sputum positive for
acid-fast bacilli. Which of the following is the principal form of defense by which the patient's body fights this
infection?
A. Antibody-mediated phagocytosis
B. Cell-mediated immunity
C. IgA-mediated hypersensitivity
D. IgE-mediated hypersensitivity
E. Neutrophil ingestion of bacteria
5.-
A 26-year-old systems analyst presents for evaluation of a bee sting allergy. He describes an episode in which he
was stung on the forearm by a bee and, within 5 minutes, experienced pruritus, urticaria, and mild wheezing. The
effector cell in this type of hypersensitivity is a(n)
A. eosinophil
B. mast cell
C. megakaryocyte
D. neutrophil
<?xml:namespace prefix = st1 ns = "urn:schemas-microsoft-com:office:smarttags" />E. TH1 CD4+ lymphocyte
___________________
leave the old behind—leave behind old behavior, old thinking, old words.
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| Novak75
Forum Senior
Topics: 3
Posts: 402
| | 05/28/07 - 12:51 AM
| #1192 |
Hi guys!, here are some questions from q bank, hope you haven't read them before, there from immuno:
1.- A 7-month-old child is hospitalized for a yeast infection that does not respond to therapy.
The patient has a history of multiple, acute pyogenic infections.
Physical examination reveals that the spleen and lymph nodes are
not palpable. A differential WBC count shows 95% neutrophils, 1% lymphocytes,
and 4% monocytes. A bone marrow biopsy contains no plasma cells or lymphocytes. A chest x-ray reveals the absence of a thymic shadow. Tonsils are absent. These findings are most consistent with:
A. Bloom's syndrome
B. chronic granulomatous disease
C. severe combined immunodeficiency
D. Waldenström's macroglobulinemia
E. Wiskott-Aldrich syndrome
2.- A researcher develops a specific antibody to the complement component C3b. Assume that
intravenous administration of the antibody prevents the biological effects of C3b. Administration
of the antibody would be expected to interfere with which of the following biological functions?
A. Decreased appetite
B. Fever
C. Increased collagen synthesis by fibroblasts
D. Increased leukocyte adherence to endothelium
E. Opsonization to facilitate phagocytosis
3.-
A 24-year-old man presents with complaints of itching on his arms and face. Physical examination reveals
hypersensitivity is this patient probably exhibiting?
A 26-year-old systems analyst presents for evaluation of a bee sting allergy. He describes an episode in which he was stung on the forearm by a bee and, within 5 minutes, experienced pruritus, urticaria, and mild wheezing. The effector cell in this type of hypersensitivity is a(n)
A. eosinophil[/size]
B. mast cell
C. megakaryocyte
D. neutrophil
E. TH1 CD4+ lymphocyte
___________________
leave the old behind—leave behind old behavior, old thinking, old words.
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| unique1
InGodITrust
Topics: 19
Posts: 1,442
| | 05/28/07 - 08:14 AM
| #1193 |
Novak , thanks for the questions. Itwould have been better if you had posted these qs, after we had done immuno , but anyway I try to answer them depending on my "intuition".
1: E
2: E
3: E
4: B
5: B
Edited by unique1 on 05/28/07 - 12:04 PM
___________________
I can't change the direction of the wind, but I can adjust my sails to always reach my destination.
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| ShweHope99.9998
Forum Fanatic
Topics: 12
Posts: 2,686
| | 03/24/08 - 12:51 AM
| #1194 |
 Almost a yr, time to bump this up for any one like to post Qs , answer here , in group here or just solo , so others will chip in .
NNL , GG ..... I maent this one , UUUUUUUUU , TG , NV , Zade , KG , AC , also new frd jena , feel free to discuss here , Q or not , thnx .
MTTTTTTTTTT , if possible , pl do b a whip here again & also organize throw some qs [ not means post real one ] , topics discussion here or the other main thread , thnx sis .
PHL also do post some pl, thnx .
GL everyone 
GL GL GL happy success study to us , all
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