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Kaplan Qbank USMLE



Author1194 Posts
  #1051

indidoc1 wrote:
PART 2- Glycogen breakdown

1-A Glucose has NO EFFECT on glycogen breakdown
2-H Most got this one right
3-D again.. Glucagon---liver
4-B. Right fr most
5-C Inc Ca is indicator fr contraction n activates MUSCLE glycogen phosphorylase.

I m beginning to develop some doubts abt 5..

Physio guys... will Ca enter the muscle if there's no stimulatory current???
if it does, my answer stands.. if it doesn't 5-A
raised eyebrow

___________________
"Whether you think you can or whether you think you can't, you're right!" ~ Henry Ford

  #1052

just checked it.. Yes.. some calcium does enter passively into muscles without AP.
http://www.jgp.org/cgi/reprint/42/4/803
So, 5-C standsnod

___________________
"Whether you think you can or whether you think you can't, you're right!" ~ Henry Ford

  #1053

thanks indidoc but poor result for part II 1 i thot glucose wud be fav food for cells if there wud be other option like lysis of gycogen oops misunderstood ....shaking headdisapproval but thanks were good questions....!smiling face

___________________
"You must feel confident enough within urself to follow your own dreams"If you think you can, you can.If you think you can't, you're right"

  #1054


Q.1 A reduction in Insulin release from the pancreas maybe caused by which of the following diuretics?





A. Acetazolamide

B. Chlorothiazide

C. Amiloride

D. Triamtrene

E. Spironolactone





Q.2 The pH of the tubular fluid can be lower than that in the proximal because





A. The brush border of the distal nephron contains more CA anhydrase than that of PCT.

B. More H+ ion is secreted into distal nephron than into proximal.

C. More buffer is present in the tubular fluid of the distal than in the proximal

D. Greater Na+ gradient can be established across the wall of the distal than across the wall of proximal.

E. The tight junctions of distal nephrons are less leaky to solute than those of proximal tubule.

Q.3 An experiment is designed to study reabsorption in the renal tubules. Rat kidneys is subjected to hormones and ions and electrophysiologic measurements are made to determine the effects for each substance. The results would most likely indicate that PO4 reasorpbtion in the PCT is increased by which of the following



A. Calcitonin

B. Increased CL- Po4 co-transporter activity.

C. Increased Na+ PO4 co-transporter activity

D. PTH

E. Increased passive diffusion





Q. 4 The daily production of H+ ions from CO2 is primarily buffered by





A. Plasma proteins.

B. RBC HCO3-

C. RBC Hb.

D. Extracellular HCO3-

E. Plamsa PO4.



Q. 5 A 38- year old man is brought to the emergency department following a car accident even though there were no observable injuries. He appears dehydrated, Plasma sample reveals elevated plasma Na+ conc. Since the patient also has a modest diuresis, An injection of ADH is given to acess the possibility of Dibetes insipid us . The ADH injection fails to terminate the diuresis . Which of the following is most likely responsible for the lack of ADH action

A. Hypoaldersteronism

B. Type 2 diabetes

C. Hyperthyroidism

D. High Na+ diet

E. Vit. D. deficiency.





Q. 6 66-year old male is brought to the emergency department after development of per orbital edema, maculopapular rah on his chest, and a fever of 101 F. Labs reveals BUN of 77 mg/dl and creatinine of 3.1mg/dl. Urine analysis shows mild proteinuria and eosinophils but is negative for glucose and ketones. The past medical history is significant for Hypertension, DM and osteoarthristis. Which of the following meds, most likely caused the appearance of his signs and symptoms





A. Clonidine

B. Metoprolol

C. Ibuprofen

D. Metformin

E. Acarbose


  #1055

Q 1. B
Q 2. B
Q 3. C
Q 4. B
Q 5. E
Q 6. dunknow guess is D


___________________
FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."

  #1056

Wake up, sleepy heads! Most of u just did these topics!!!!! cool

  #1057

1.b

2.b

3.c

4.d

5.????

6.c


___________________
"You must feel confident enough within urself to follow your own dreams"If you think you can, you can.If you think you can't, you're right"

  #1058

Mytime: You know i know them all, so i get exempted rtgrin

Indidoc:Glycogen Breakdown part.........i still think the answer to

1. E (We have Glycogen Breakdown at y axis this time & Time at x axis.) To be at some point on the Y axis shows that Glycogen breakdown is taking place at some rate. If you give glucose to liver, Glycogen synthase should be stimulated leading to glycogen formation. This will cause a decrease in the rate of glycogen breakdown in liver.
Muscle however i agree has no effect and is a straight line.

5. A( because it needs the Calmodulin mechanism which wont be activated till there is an impulse). Little Ca currents which are always there does not activate Calmodulin.

Just a little thought from my side and i stand by it until proven otherwisewink

CIAO


Edited by focusmle on 03/06/07 - 08:39 AM

  #1059

1.b

2.b

3.c

4.d

5.b

6.c


  #1060

okay, i'm scared to answer these Qs, but whatever.........wonder if my name will work this time!!!
1. B
2. B
3. E
4. E
5. B
6. A

___________________
The intellect works with the greatest intensity when it works continuously; the more you do, the more you can do - Oswald Chambers.

  #1061

ok.. i n focus discussed the glycogen breakdown Q..

We agree that 1 stays A as before..

The point of contention is 5.. its between A ans C.. We ll have to look up the role of action potential and calmodulin in this.. Good observation, focusnodnod

n MT.. i can't try hardcore renal Qs yet.. sorry sad

___________________
"Whether you think you can or whether you think you can't, you're right!" ~ Henry Ford

  #1062

focus i agree for 1st but dnt u think once tissue sees glucose his fav food he will stop breakdown of glyco and start synth....so it striaght line for both liver n muscle...sorry if misunderstood ur point....plz share


___________________
"You must feel confident enough within urself to follow your own dreams"If you think you can, you can.If you think you can't, you're right"

  #1063

Dear KG .......Just a lil correction to what you said. Muscles wont make glycogen from simple glucose if insulin effect is not present ok. Rest is all fine.
I believe i just overthinking on some point and i dont want to confuse you.

5 is A and i managed getting my way out here. So if u need to know why, i am here.nod



Edited by focusmle on 03/07/07 - 05:04 PM

  #1064

15 Qs together.. try it .. timed

http://www.geocities.com/sendmyscore/

___________________
"Whether you think you can or whether you think you can't, you're right!" ~ Henry Ford

  #1065

thanks focus but my point was not to emphasi on muscle taht part we understood but had confusion in liver so asked ...rate limiting enzyme for glycogen breakdown is glyc phosphor rt?it is inhibited by glucose..thats it...but if u saying i cantd eny coz u know better and wud love if u plzz explain me ur point of view...im saying it will not slow down but stop and u said it will decline..rt?plz help me if im wrong i need to correct myself if u dont mind and have time...

thankssmiling face


___________________
"You must feel confident enough within urself to follow your own dreams"If you think you can, you can.If you think you can't, you're right"

  #1066

thanks indi i tried n got 63% ....goodones..

hey mytime whn gonna post ans to ur questions???


___________________
"You must feel confident enough within urself to follow your own dreams"If you think you can, you can.If you think you can't, you're right"

  #1067

Hey KG......i think you are fine sweetie. Let me just summarize stuff here then.

In liver, upon giving Glucose, Glycogen synthase will be further activated to make Glycogen.
Glycogen phosphorylase however will work at the same pace to break down Glycogen no matter what (as far as there is Glycogen available). So we go for a straight line for glycogen breakdown in the middle of the graph.

As far as Muscle is concerned........i just think about guys not liking Mithaaes and so Glucose wont form glycogen in muscle till there is Insulin, just my way of remembering stuff grin

  #1068

so any Glycogen available for breaking down by Glycogen Phosphorylase in muscle just goes on at its regular rate till Glycogen is depletedsmiling face



  #1069

1. B

2. B

3. C

4. C

5. B

6. C




___________________
Malcolm Forbes: Victory is sweetest when you've known defeat

  #1070

I was waiting for U. and K. to attempt these but I'm posting the ans. Please go read for explainations, if u still don't get it. I'll put it down.

1. B

2. E

3. C

4. C

5. B

6.C
winkgrin



Edited by mytime on 03/08/07 - 02:06 PM

  #1071

thanks mytime...it wud be sweet of u if u post explanation as well if u have...very good questions....smiling face

focus--thanks deary well u know where confusion arose for me..i was considering oral glucose but ur explanation --> it should be glucose IV

HEY INDIDOC PLZZ POST THAT WAS ORAL OR IV GLUCOSE?????????well whatever was concept is clear i think focuswinki assumed oral glucose-->stimulate insulin -->both liver n muscle will stop gyl breakdown...

thanks focus that was sweet way of memeorization...now guyz cant refuse candy(sugar)if given thru lady insulin wink


___________________
"You must feel confident enough within urself to follow your own dreams"If you think you can, you can.If you think you can't, you're right"

  #1072

LOLgringringringrin
KG, thats what happens when u argue wth focus.. gringringrin
u end up getting confused n she comes out on top sticking out tonguesticking out tonguesticking out tongue

There's no question of IV or oral glucose here buddy.. There's no extra pancreas in a tissue culture to release "LADY INSULIN"wink
everything is directly bathing the cells..
But i know there's nothing wrong at ur end... Rest assured.. i call it the "FOCUS" effectwinknodgringringrin

___________________
"Whether you think you can or whether you think you can't, you're right!" ~ Henry Ford

  #1073

lol grin rt i forgot main part of ur question i.e vitro study but no confusion for anything else what i said is 100%rt nod in vivo its not focus effect it neglect effect....if was focused thn i wud have not made this mistake.wink thanks for correcting indidocsmiling face btw this was 1st discussion with focus wink thanks focus!!!

___________________
"You must feel confident enough within urself to follow your own dreams"If you think you can, you can.If you think you can't, you're right"

  #1074

and lady insulin WILL ALWAYS have gr8 impact on muscle to get candy(sugar) like mytime's whip effect on u grin grin

___________________
"You must feel confident enough within urself to follow your own dreams"If you think you can, you can.If you think you can't, you're right"

  #1075

LOL grin KG:yeah so i was just giving u an overall pic. if Insulin is there invitro or invivo along with glucose oksmiling face

Indidoc.......why would u spare me when i dont spare u rtgrin grin







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