Cedrick
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A series of experiments is performed to determine the mechanism by which a pharmacologic agent traverses cell membranes and accumulates within target cells
the rate of transport dependes on the concentration of the drug only
when the extracellular concentartion of the agent exceeds 10mM
no further increase in the rate of uptake is observed
structurally similar compounds pass through the cell membrane,but at a lower rate
Ouabain,an inhibotor of Na/K ATPase,fails to inhibit transport which of the following is the most likely mechanism by which this agent eneters cells ??
a.-antiport
b.-facilitated diffusion
c.-ion gated coupling
d.-simple diffusion
e.-symport
it may have been discussed before but I can't see ot find a good answer
thanks
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| Cedrick
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B
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| disha
Forum Senior
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its b bcoz its a faciliated diffusion depending on conc gradient,but it says that it allows structurly similar comp to pass at a lower rate probably indicating a carrier mediated transport.
oabain fails to inhibit it bcoz its not an active pump.
plz correct me if im wrong
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| Cedrick
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| reet
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B yes.
from question==
extracellular concentartion of the agent exceeds 10mM
no further increase in the rate of uptake is observed
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| Diego Casali
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I agree.
B
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| eaguin
Forum Senior
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B
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