| Author | 9 Posts |
nadiabarati
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48. A 50-year-old woman comes to the physician because of a visible painless lump in her neck for the past 6 months. Her pulse is 80/min, respirations are 14/min, and blood pressure is 120/70 mrn Hg. She has an enlarged, nontender thyroid gland. Initial thyroid function studies are normal. Her serum thyroid-stimulating hormone (TSH) concentration is 15 ìU/mL, and serum thyroxine (T4)concentration is 3.5 ìg/dL Which of the following describes the most likely pathologic findings in her thyroid gland?
A) Absence of thyroglobulin
B) Heavy lymphocyte infiltrate with germinal center formation
C) Noncaseating granulomas
D) Presence of an antibody that simulates the action of TSH
E) Regenerative nodules with lakes of excess thyroid proteins
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| sridevibandaru24
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B
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| nadiabarati
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agree it's Hashimato. right?
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| robin082006
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right
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| Cedrick
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B
Yes Hashimoto .-hypothyroidism
named after the japanese phisician
{I did not know this history fact}
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| Diego Casali
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B
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| qumsieh
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Definetly B) Hashimoto's Thyroiditis. Characterized by Autoimmune lyphocytic infiltration of the thyroid gland. 8:1 ratio in women to men. As most autoimmune starts between 30-50. Now remember this also, if same presentation except added endocrine disorder its not Hashimoto's its called Schmidt's syndrome with is basically Hashimoto's and endcrine combined. Example would be disorders such as diabetes or addison's disease combined with Hashimoto's. Hashimoto's is diagnosed by hypothyroid S&S. Antimicrosomal antiboidies may be present. These are antibodies against the peroxidase. Treatment is permanent thyroid replacement. Upon fine needle aspiration, lymphoid follicles with germinal centers & HURTHLE cells!!!! Hope this helps!
Ross University Graduate
Massachusetts General Hospital
Harvard College
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| SmokyWaters
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AIRE
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| SmokyWaters
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Autoimmune polyendocrine syndrome, type 2 (also known as "Schmidt's syndrome") is more heterogeneous, occurs more often and has not been linked to one gene. Rather, patients are at a higher risk when they carry a particular HLA genotype (DQ2, DQ8 and DRB1*0404).
Features of this syndrome are:
Addison's disease
hypothyroidism
diabetes mellitus (type 1)
less common associations:
hypogonadism
vitiligo
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