rman
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3. A rock climber has been stranded on a vertical cliff for several hours without food. His increased energy demand is met in part by release of alanine secondary to muscle protein catabolism. Which of the following best describes the fate of alanine following its release in this individual?
A ) Conversion to acetoacetate
B ) Conversion to malate
C ) Conversion to pyruvate
D ) Use as a nitrogen source for carnitine
E ) Use as a nitrogen source for synthesis of essential branched-chain amino acids
F ) Use for the excretion of amino nitrogen
C
Can anyone explain the biochemical changes in starvation, please??!!
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| rman
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Starvation: Body generates glucose from muscle protein ; brain generates glucose from Bhydroxybutyrate from FA breakdown. CORRECT????
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| robin082006
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C
For starvation it is depend on how long you one abstain.
See the figure in Kaplan Biochemistry
Edited by robin082006 on 06/22/06 - 12:59 AM
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| rman
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so, short term: deplete hepatic glycogen stores (1d), then for a few days go via gluconeogensis which is from protein. then there is a switch from protein to fat for the brain. here, the body generates glucose from muscle protein whereas brain generates glucose from Bhydroxybutyrate from FA breakdown thereby generating ketone bodies
basically, my main confusion is: in longterm starvation (say a week), does the body (not brain) generate glucose from MUSCLE(protein?) glycogen??
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| mjl1717
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alanine---enzyme- alanine transaminase+ vitaminB6---pyruvate. {this is reversible}
Id say beta hydroxybutyrate is an end product or a ketone that the brain would only use under etrememely stressful circumstances..
And as robin is saying it depends how long you abstain.
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