Cedrick
Esculapio
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A 75 year old man is brought to the physician by his family becauseof akinesia,rigidity,postural instability,and tremor
Symptoms improve with levodopa therapy,but he develops anorexia,nausea,vomiting and mild orthostatic hypotension
a drug with which of the following mechanisms of action is most appropiate to decrease the gastrointestinal symptoms and hypotension
a.-inhibition of catechol-O-methyltransferase
b.-inhibitionof monoamine oxidase B
c.-inhibition of peripheral dopa decarboxylase
d.-stimulation of cholinergic receptors
e.-stimulation of dopamine receptors
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| reet
Forum Fanatic
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C. INHIBTION OF PERIPHERAL DOPA DECARBOXYLASE..
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| Cedrick
Esculapio
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yeah you are right it is the only one that makes sense
thanks I guess I am just tired
Thanks for the fresh eyes
choice C
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| nadiabarati
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C
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| docarchana
Forum Guru
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yes C..
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| klimt
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drug's name is carbidopa
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| smal
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from what i understood,pt is already on levodopa,and which drusg is to be given to dec peripheral met. side effects..........so A.
tolcapone an COMT inhibitor.
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| NE
Forum Guru
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yes, his treatment is LDOPA but the goal is to decrease the side effects so carbidopa is the choice; you can decrease the dose with the same effect for motion problem and with few side effects.
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