Cedrick
Esculapio
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A 22 year old man comes to the emergency department because
of the sudden onset of excruciating chest pain that radiates to his back
his pulse is weak and rapid
A CT scan of the chest shows a fluid density within the aortic wall
A defect of which of the following proteins is most likely in this patient ?
a.-elastin
b.-fibrin
c.-fibronectin
d.-integrin
e.-laminin
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| alexaE
Forum Elite
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a
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veni vidi...vincam
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| spjokes
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This is Aortic aneurysm in MARFANs SYNDROME.
This is caused due to an inherited defect in an extracellular glycoprotein called FIBRILLIN.
CEDRICK could you please say if B is fibrillin? Thank you for sharing nice questions
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| alexaE
Forum Elite
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yes its fibrillin, but wasnt among the answers.. so i went with elastin, though i know its not the exact choice
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| sridevibandaru24
Forum Guru
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A
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| mildus
Forum Guru
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as I remember fibrillin is part of elastin
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| Cedrick
Esculapio
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Yes on this is choice A
and in another question that I just did
it is Fibrillin
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| spjokes
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If you say that the answer is ELASTIC FIBERS. I Agree.
Because Elastic fibers consist of a central core made of ELASTIN, surrounded by a network of microfibrils. The peripheral microfibrillar network that surrounds the core consists largely of FIBRILLIN.
I think ELASTIN is not correct.
Is there anyone to support this view?
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| Cedrick
Esculapio
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Fibrillin then elastin
so yes sorry my spelling is really bad when done fast
Yes B
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| shilahk
Forum Senior
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i read in goljan that Dissecting aortic aneurysm is due to elastic tissue fragmentation (95%) with or without cyctic medial necrosis in the media that wekens the aorta and leads to dissection.......so that might match into the choice elastin
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| rman
Forum Senior
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Okay, so the answer is B, right? FIBRILLIN?
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