Cedrick
Forum Fanatic
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a 50 year old man undergoes allogeneic bone marrow transplantation for relapsed acute lymphocytic leukemia that includes pretreatment
with total body irradiation.
his HLA profile is HLA-A1,-A 10,HLA-B7,-B18 and HLA-Cw1-D
The donor bone marrow cells have the following HLA profilr,HLA-A3,-A9,HLA-B7,HLA-Cw2,-Cw3
Three months after the transplant,the patient is diagnosed with graft-versus-host disease {GVHD},he dies 1 month later
which of the following best describes the pricipal immune mechanism resposible for GVHD in this patient ?
a.-activation of donor cell derived natural killer cells
b.-donor cell derived innate immune responses directed against disparate MHC antigens
c.-donor T-lyphocyte-mediated suppressionof bone marrow hematopoiesis
d.-generation of donor B-lymphocyte antibody responses directed against disparate host MHC antigens
e.-generation of donor T-lymphocyte responses directed against disparate MHC antigens
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| nadiabarati
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e
it's exactly the definition of GVH
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| star1
Forum Guru
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E 
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| Cedrick
Forum Fanatic
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I agree
E
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| robin082006
Forum Hero
Topics: 471
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E
___________________
The Key to Succeed is Patience.
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| sridevibandaru24
Forum Guru
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E
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