rman
Forum Senior
Topics: 39
Posts: 123
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Endothelial cells of the postcapillary venules increase expression of intercellular adhesion molecule-1 (ICAM-1) in response to cytokines. The increased expression of ICAM-1 results directly in which of the following neutrophil functions?
A) Activation
B) Adherence
C) Chemotaxis
D) Demargination
E) Transmigration
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| rman
Forum Senior
Topics: 39
Posts: 123
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I think B is the distractor. It's C, right? because it acts in this context as a homing molecule...?? Does anyone have any good info on adhesion molecules? Eg, selectin, integrin, ICAMs. Some URL links?? Anything? Anyone wanna post some basic info on this?
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| robin082006
Forum Hero
Topics: 471
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B is the answer
Here is the key (Kaplan note)
- CD4 and CD8 transduce activating signals to T cells
- Integrins on T cells (LFA-1) bind to IgCam on APCs (ICAM-1)--> increase cell-cell adherence
- IgCAM on T cells (CD2) bind to Integrins on APCs(LFA-3)--> increase cell-cell adherence
- CD28 on T cells bind to B7 on APCs--> increase the transcription of cytokine genes
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The Key to Succeed is Patience.
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| alexaE
Forum Elite
Topics: 23
Posts: 334
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remember
rolling: selectins
adhesion: integrins and ICAMs
transmigration: PECAMs
so the answer is B
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veni vidi...vincam
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| nadiabarati
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also consider the word directly in the Q.
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| spjokes
Forum Senior
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Posts: 88
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ADHESION ---------> ARREST ----------------> TRANSMIGRATION (all Leukocytes).
IF IT IS ONLY ONE ANSWER I WILL GO FOR ADHESION.
Please read last and last but one paragraph on page 54 Robbins (e- 7).
I find the tabular column in this page very helpful.
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| rman
Forum Senior
Topics: 39
Posts: 123
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Thanks folks!
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