mjl1717
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What is a B2 Microglobulin used for?
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| drkirangm
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i think it is used as a prognostic marker of multiple myeloma right?
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| meg
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it is the amyloid after chronic dialysis.
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| mjl1717
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Its part of the Major Histocompatibility Complex or HLA. Its the light Beta chain that functions to transport MHC class I molecules to the cell surface
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| drrabines
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and It is not sinthezised by the MHC, it carries the MHC I molecule superficial.
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| ru
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the T lymphocytes from the patient with a deficiency of b2 microglobulin in bone marrow stem cells be unable to
a.synthesize IL-2 or inf gamma
b. express CD3
c. express the T-cell antigen receptor
d. recognize antigenic peptides presented by a Bcell
e. specifically kill virus-infected macrophafes
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| mjl1717
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answer-c
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| ru
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the answer is c
"bmicroglobulin is a part of MHC class I molecule and is required for MHC class I expression.Since MHC classI molecules provide the peptide-binding site for cytotoxic T-cell killing of virus-infected cell, a virus-infected macrophage(bone marrow derived) could not be recognizid by cytotoxic Tcell"
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| mdwannabe
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what about B1?
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| rida
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Correction to this guys, the question ru gave, the answer is not C, but actually E, i came across this question in my kaplan book and thats the answer they gave us, i think ru prob made a typo, and typed c, but just wanted to cleaer that up.
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