DrVirgo
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Drug A: need 60mg for pain relief
Drug B: need 4mg for pain relief
So which drug is more potent, and by how much?
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| mjl1717
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b is more potent you need less, its closer to y axis. Im not sure how to quantify it but it only takes a few mgs to reach the same efficacy.
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| DrVirgo
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Thats right. B is more potent than A. B is 15 times more potent.
(Also note: Potency does NOT indicate anything about duration of action, toxicity, margin of safety or Vd.)
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| robin082006
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Of course in this case B is the answer because it reaches a threshold to relieve pain at lower dose.
We can assume that drug B is 15 time more potent than drug A (60/4=15). Provided that pain in the same patient (has the same pain intensity).
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| robin082006
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Another e.g
Drug A: need 60mg for pain relief in patient with myocardial infarction
Drug B: need 4mg for pain relief in patient with chronic arthritis
what drug is more potent?
WE CANNOT ANSWER THIS QUESTION.
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| robin082006
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TRY THIS QUESTION
In a patient,
Drug A, produces 50% effect at dose 50, reaches its maximum effect at dose 100
Drug B, 50% effect at dose 25, maximum effect at dose 150.
which one is more potent, which one is more efficicacous?
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| asherif
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B more potent
and we can't tell about efficacy.
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| DrVirgo
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B is more potent to achieve 50% and 100% effect.
Efficacy: both the same or can't say?
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| robin082006
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Excellent Asherif, 100% you're right
we cannot say about efficacy because we do not know how much of their effect.
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| DrVirgo
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We do know the dose at which each drug reaches a maximal effect, so.....???
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| robin082006
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no need to know the dose at which the drug reaches its maximal effect, we just want to know how much its maximal effect is.
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