mjl1717
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Can anyone describe Type II hypersensitivity in detail and give 7 diseases?
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| asmi
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Type II hypersensitivity or antibody mediated hypersensi... is
*Mediated by IgG or IgM antibodies against tissue antigens.
*antibody binds to cells or tissues and causes local complement activation,influx of leuckocytes,tissue destruction because of ADCC,degranulation by phagocytes,oxygen radicals.
*results in organ specific antibody production
*effector cells are PMN,Macrophages,NK cell
*Examples: hemolytic disease of newborn.
Graves disease
myasthenia gravis
goodpasture syndrome
autoimmune hemolytic anemia
autoimmune thrombocytopenic purpura
hyperacute graft rejection
rheumatic fever
transfusion reactions
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| alice8
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Examples of cell injury in which antibody reacts with antigenic components of a cell are
Coombs'-positive hemolytic anemias,
antibody-induced thrombocytopenic purpura,
leukopenia,
pemphigus,
pemphigoid,
Goodpasture's syndrome,
pernicious anemia.
multisystem hypersensitivity diseases (eg, SLE).
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| mjl1717
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Also Type II works on the surface
I always see SLE as TYPE III!!!
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| asmi
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What does works on surface means?
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| mjl1717
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Cytotoxicity occurs when antibody is directed aginst epitopes that occur on the SURFACE membrane of host cells
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