DrVirgo
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Any ideas???
Naloxone is an opioid antagonist so it should decrease respiratory depression if given before morphine, but which curve is right?
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| nadiabarati
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I think C
naloxone is an competitive inhibitor?
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| alexaE
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C
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| DrVirgo
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why C and why not B? Thanks.
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| nadiabarati
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compare with enzymes, Vmax and Km....
competitive inhibitors doesn't decrease the maximum result but increase the dose of the original substrate, morphine here, for getting the same result. The dose of morphine must be increased to overcome its competitive inhibitor.
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| robin082006
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yeah C
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| robin082006
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C for competitive antagonist
B for partial agonist
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| DrVirgo
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Thanks. 
What drug would be an example of a partial agonist (B)?
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| robin082006
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Tramadol is a partial agonist of Morphine
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| DrVirgo
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ok 
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| antidepressant
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competetive antagonis cause a paraller shif to the right in the D-R curve for agonist., can be reversed by increase dose of agonist, decrease potency of the agonist.
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