karusmle
Forum Guru
Topics: 296
Posts: 1,001
|
amount of plasma uric acid??
|
| MAZI
Forum Elite
Topics: 8
Posts: 245
|
|
| achilles
Forum Guru
Topics: 90
Posts: 1,228
|
3-urine pH ?
___________________
" it's not whether you get knocked down, it's whether you get up"
" i have miles to go before i sleep "
|
| MAZI
Forum Elite
Topics: 8
Posts: 245
|
ok achilles
I,m waiting for your explanation.
|
| achilles
Forum Guru
Topics: 90
Posts: 1,228
|
uric acid stones are usually associated with acidic urine. and calcium stones are associated with normal pH urine.
one of the treatments in uric acid stones is thus alkalinisation of the urine as it dissolves the uric acid stone.
___________________
" it's not whether you get knocked down, it's whether you get up"
" i have miles to go before i sleep "
|
| Jinx
Forum Elite
Topics: 17
Posts: 316
|
thanx achilles!!
___________________
Life is a journey--enjoy the drive!!
|
| MAZI
Forum Elite
Topics: 8
Posts: 245
|
dear achilles
your explanayion is enough the monosodium urat(MSU) crystal not precipitate in alkalin urine.
hei men whats your explanation about apnea defenition,s question
|
| achilles
Forum Guru
Topics: 90
Posts: 1,228
|
thanks for checking mazi.
sorry but dont know the answer to your apnea question.
___________________
" it's not whether you get knocked down, it's whether you get up"
" i have miles to go before i sleep "
|
| AAAAA
Forum Fanatic
Topics: 156
Posts: 1,991
|
citrate, citrate, citrate !!!!
Medical Care: The primary treatments are to alkalinize (citrate or bicarbonate) and dilute (large water intake) the urine. Sodium urate is 15 times more soluble than uric acid. At a urine pH of 6.8, 10 times as much sodium urate as uric acid is present. At a urine pH of 7.8, 100 times as much urate as uric acid is present.
___________________
seeking study partner in USMLE, Canadian MCC OSCE examination
|
| AAAAA
Forum Fanatic
Topics: 156
Posts: 1,991
|
Background: Uric acid stones are the most common cause of radiolucent kidney stones in children. Several products of purine metabolism are relatively insoluble and can precipitate when urinary pH is low. These include 2- or 8-dihydroxyadenine, adenine, xanthine, and uric acid. The crystals of uric acid may initiate calcium oxylate precipitation in metastable urine concentrates. The interested reader should read the related article Xanthinuria.
The terms gouty nephropathy, urate nephropathy, and uric acid nephropathy are used to describe renal insufficiency due to uric acid precipitation within the renal tubules.
Uric acid urolithiasis or uric acid kidney stones refer to development of a stone or calculus composed of significant amounts of urate in the renal pelvis, ureter, or bladder.
Pathophysiology: Uric acid is a weak acid with a pK of 5.8. At pHs below the pK, it exists predominately in a nonionized form. The urate ion is more soluble than the nonionized molecule. Urate ions (predominate form at pH 7.4) are about 5% protein bound. Urate is filtered at the glomerulus. The renal tubule can reabsorb (movement of urate from tubule lumen to peritubular fluid) or secrete (movement of urate from peritubular fluid into tubular lumen) urate. Typically, net reabsorption occurs in infants and children. The fractional excretion of urate in infants and children ranges from about 0.10-0.60 (
___________________
seeking study partner in USMLE, Canadian MCC OSCE examination
|
|
| |
| | | | | | | | | | |
Similar forum topics