NBME form 2: pregnancy glucocorticoid levels

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NBME form 2: pregnancy glucocorticoid levels

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5 Posts

itsmefarah
Forum Newbie

Topics: 1
Posts: 1

06/12/06 - 09:47 AM

Hey guys,

There was a question about a woman in her 2-3 trimester and why, in pregnancy, increased GCC levels does not result in significant catabolic damage. Is this b/c of increased

A. Auto-AB's to GCC
B. Metabolic clearance of GCC
C. Steroid binding protiens
D. Steroid binding receptors
E. Steroid uptake mechanisms.

Any ideas?

Thanks!

Geroo
Forum Guru

Topics: 114
Posts: 799

06/12/06 - 09:57 AM

C. Steroid binding protiens

surgeon99
Forum Senior

Topics: 9
Posts: 98

06/12/06 - 01:28 PM

Yes it is because of increase in Steroid binding protein. Also Total T4 increses in because of increase in Thyroid binding protein ( because of estrogen )

robin082006
Forum Hero
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Topics: 471
Posts: 5,123

06/12/06 - 01:38 PM

C

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drpkaur
Forum Guru
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Topics: 196
Posts: 810

06/15/06 - 08:46 AM

It's c ..because in pregnancy,estrogen levels are high ,it leads to increase in binding proteins(cortisol,thyoid binding globulins)this leads to increased total fraction of the hormone that is the bound fraction but the free unbound biologically active fraction remains constant...that's why no signs of hyperfunction ..

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