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Kaplan Qbank USMLE



Author4 Posts
  #1

What is the cause of female pseudohermaphrodism?

  #2

Adrenogenital syndromes 11-OH deficiency and 21-OH deficiency

17-OH deficiency causes male pseudohermaphrodism

I cant think of any other cause rightnow!

  #3

female pseudohermaphroditism means genetically they are females but external genitalia resemble male.
Over expression of adrenal 17 keto steroids as mentioned by 'Guest' are the cause.

  #4

To make this a little more sequential

F.P as meg says genotypic female XX ,ovaries, but virilized genitalia

.
1)*androgen exposure in 1st trimester
2)MC due to congenital adrenal hyperplasia-21 HYDROXYLASE DEF.
3)Gene coding for 21 Hydroxylase is inactive.
4)To produce cortisol excessACTH is made which stimulates
5) 17 Hydroxyprogesterone and adrenal andogens
6)can also be caused by 11 OH def, 3 OH def or synthetic progesterones
during first trimester

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