mitty
Forum Guru
Topics: 52
Posts: 376
|
your patient,a 32 year old caucasian female,presents to you with SLE.she is suffering from glomerulonephritis & rheumatoid d/s.She has no hx of recurrent bacterial infections,edema or neisserial infection.As far as the complement system is concerned,which of the ff is your patient most likely deficient ?
A ) C3
B) C4a &C4b
C) C1-INH
D) C6 &C7
E) C9
___________________
He will make it happen.
|
| doc179
Forum Guru
Topics: 67
Posts: 1,217
|
A ?
|
| robin082006
Forum Hero
Topics: 471
Posts: 5,123
|
A
___________________
The Key to Succeed is Patience.
|
| tolito
Forum Fanatic
Topics: 119
Posts: 2,174
|
A. C3 binds Ig so the level will be low??
___________________
It has been a looooong hard journey but I am inches away from my destination...
|
| mitty
Forum Guru
Topics: 52
Posts: 376
|
Try another one.My answer was A too but I was wrong.
___________________
He will make it happen.
|
| tolito
Forum Fanatic
Topics: 119
Posts: 2,174
|
mitty, yes A is wrong!! it must be C1 inh. cos lack of it leads to uncontrolled complement activation. if i am wrong this time, i will not eat for 3 days.
___________________
It has been a looooong hard journey but I am inches away from my destination...
|
| divya888
Forum Senior
Topics: 6
Posts: 27
|
C9
|
| mitty
Forum Guru
Topics: 52
Posts: 376
|
tolito, the answer is B.And here is the explanation
Deficiency in C3 may result in glomerulonephritis,but would also involve recurrent bacterial infection.(the patient in the q has no such hx)
90% of individuals lacking C4a & C4b develop SLE. In their absence,C3 doesn't bind immune complex.Lack of C3 binding immune complexe results in decresed clearance of the complexes from the blood & subsecuent immune comples deposition through out the body.This initiates some the SXs associated with SLE.(C2 deficincy also have d/s resumbling SLE but it is not in the choice)
Lack of C1-INH results hereditary angioedema
Def. in C6& C7 results in recurrent neisserial infection
Def in C9 =recurrent nesserial infection.
___________________
He will make it happen.
|
| doc179
Forum Guru
Topics: 67
Posts: 1,217
|
Thanx for the right ans and explanation mitty.
|
| tolito
Forum Fanatic
Topics: 119
Posts: 2,174
|
mitty, there goes food for 3 days.
i saw the lack of edema but i disregarded it when i chose C1inh.
good question
___________________
It has been a looooong hard journey but I am inches away from my destination...
|
| mjl1717
Forum Hero
Topics: 960
Posts: 5,468
|
good q.
As I recall C5 -C9 is for neisseria infections.
C3b is with opsonins , not sure of C3?
{by the way ill share a veggie burger with tolito}
___________________
Smell the coffee! "Is That an Osler move??"
|
|
| |
| | | | | | | | | | | |
Similar forum topics