DrVirgo
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Norepi stimulation of Gq proteins results in increased IC concentration of calcium. Which of the following is the most likely cause of the increased IC Calcium concentration?
A. Arachidonic acid
B. cAMP
C. cGMP
D. 1,2 DAG
E. IP3
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| mjl1717
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IP3
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| Slacker
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E.
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| sridevibandaru24
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E
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| DrVirgo
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agree. E
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| Addicudo
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Why aint it D ... as Gq --- Phospholipase C --- DAG, IP3 and Ca+ ... So why IP3 and not DAG ?
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| jean robert
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E
Phospholipase C hydrolyzes PIP2, a phosphatidylinositol, into two second messengers, inositol triphosphate (IP3) and diacylglycerol (DAG).
IP3 stimulates the release of calcium ions from the smooth endoplasmic reticulum while DAG is still membrane associated and activates protein kinase C (PKC).
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