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Author8 Posts
  #1

the sickling of erythrocytes in patients with sickle cell disease results from which of the following ? a.-aggregation and polymeration of the sickle cell hemoglobin HbS b.-inability of HbS to bind heme
c.-inability of the HbS molecules to form a tetramer
d.-instability of the HbS molecules Thanks



  #2

A

  #3

A

  #4

upon deoxidation HbS can not produce tetramers and rather forms long polymers. So I think A and C are right! What is wrong with my thought?!!

  #5

Why can't it be D. The HbS are instable and that causes spontaneous sickling of the RBCs. Also low PaO2 can cause sickling in a person with Sickle cel trait.


  #6

it bends and deforms the cell, A

  #7

HBS can polymerise upon low O2 tension or hypotonic stress. The polymerized HBS deforms RBC.

  #8

Where can we look this up? I think its either C or D.

Factors that induce sickling are:
-HbS in RbC>60%
-Reduced O2 tension
-High altitude
-Low O2 tension in the renal medulla
etc....

But what about the structure of the Hb?




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