drpkaur
Forum Guru
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hi guys ,why edema doesn't occurs in primary hyperaldosteronism (Conn's syndrome)as there is increased aldosterone secretion which leads to increased Na reabsorption,Na retention leads to water retention too ,therefore ECF volume increases plasma volume increases then why not edema occuring in this situation ...and why edema occurs in secondary hyperaldosteronism...anyone can explain it
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| ndspider
Forum Senior
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Well.
When you think of aldosterone think of Na and K NOT H2O. Although H2O comes with the NA.
The main hormone that deals with H2O is ADH.....
keep it simple
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| doc179
Forum Guru
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as far as I remember the books said because of some Na leak back into the tubules in primary, which is not present in secondary hyperaldosteronism is the reason. Looks like the mechanism is not well understood.
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| sridevibandaru24
Forum Guru
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According to Kaplan's physiology, a major increase in sodium and water retention is prevented by sodium escape in primary disorder. Although mechanism is not understood,evidence exists for the role of Atrial Natriuretic Peptide
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| mildus
Forum Guru
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You said that blood volume increases, so blood pressure is also increased. Increased blood pressure causes glomerular filtration rate to increase by pressure-diuresis and pressure-natriuresis mechanism, as explained by AC Guyton. So, diuresis is increased and blood volume remains constant so there is no oedema.
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| brain!
Forum Newbie
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in primary hyperaldosteronism which is due to adenoma of adrenal gland mainly, renin level is low as its obvious why? cus large amount of aldosterone is produced and in order to compensate that renin level has to be low as a negative feed back so we dont ve edema in primary hyperaldosteronism .
in secondary hyperaldosteronism...one of its cause is decreased renal blood flow so its clear that when blood flow to the kidney is decreased renin flow will increase in compensation and so when renin level increases it will conserve Na and water and so we get edema in secondary hyperaldosteronism..! other causes of seconadry hyper aldosteronism include CHF,bartter syndrome and renin producing tumors,so here is a big one..renin producing tumor an obvious cause of edema due to increased load of renin!
please correct me if iam wrong!
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| brain!
Forum Newbie
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in short i would say ...
primary hyperaldosteronism..........renin level is low!
secondary hyperaldosteronism..........renin level is high!
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| xwxf
Forum Senior
Topics: 16
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This phenomenon is called Sodium Escape. The mechanism hasn't been fully understood. One probability is that aldosterone cause isosmotic expansion of ECF.
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| study_ing
Forum Fanatic
Topics: 180
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well i have a 'goljan' suggestion
edema by definition means increase in interstiial fluid..
hence increase in Na ( limited to ECF) rather than water ( ICF + ECF) is likely to coz edema
in SIADH there is no edema as
u gain water, not salt
the increase in plasma volume means more sodium loss at the proximal tubule level (high flow means less reabsorption)
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