vallia
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A pharmacologist is determining the pharmacokinetic parameters of a novel
antibiotic in order to determine the proper dosage. The drug is a
weak organic acid with a pKa of 3.0. Assuming a pH of 2.0 in the
stomach, approximately what percent of the drug will be in a form
that can be rapidly absorbed from the stomach?
A. 0.1
B. 1
C. 10
D. 50
E. 90
F. 99
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| doc179
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E
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| star1
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E 90
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| sridevibandaru24
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E
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| robin082006
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agree
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| vallia
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| waqastariq
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e
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| fox
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cud somebody xplain pls?
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| ManuNastai
Transilvanian..
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the drug is a weak acid, so the lipis soluble form is the protonated form. so:
pKa-pH=log [protonated]/[unprotonated]
3-2=1 =>
10= protonated/unprotonated
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