MDcooper
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Infectious mononucleosis is chracterized by all except
1.antibodies to EBV
2.heterophilic antibodies
3.antinuclear antibodies
4.anti I antibodies
5.antibodies to sheep RBCs
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| Isther
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Not sure... but is between ANA and anti-I. ANA is for rheumatic diseases, and anti-I for cold agglutinin diseases...Has to be one of those.
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| cyra
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3.antinuclear antibodies
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| guayoman
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What is anti-I?
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| AAAAA
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Anti-I/i Plus Anti Pr Cold Agglutinins in Individual Sera
D. Roelcke, A.L. König, U.T. Seyfert, A. Pereira
Address of Corresponding Author
Infusion Therapy and Transfusion Medicine 2000;27:149-153 (DOI: 10.1159/000025260)
Summary
Background: Sera with high-titer cold agglutinins (CAs) of unclear or even of apparently definite specificity may contain mixtures of CAs with different specificities. The combination of anti-I plus anti-Sia-b1 CAs in sera of patients with Mycoplasma pneumoniae infections is well documented. No systematic studies on CA mixtures in sera of patients with other diagnoses are available. Material and Methods: Sera of 322 patients with high-titer CAs were exhaustively absorbed with sialidase-treated red blood cells (RBCs). By absorption, CAs against the sialidase-resistant I/i antigens are removed. If CAs reacting with untreated RBCs are left after absorption, they are directed against the sialidase- and protease-sensitive Pr1,2,3 antigens or against the sialidase-labile but protease-resistant antigens of the Sia-I/b/Ib complex. If CA mixtures were found, specificities and isotypes of the CAs obtained by cold adsorption and warm elution were determined. Results: Three patients had mixtures of anti-i plus anti-Pr CAs, 2 patients had mixtures of anti-I plus anti-Pr CAs. Conclusion: The occurrence of CAs directed against biochemically different antigens in individual sera proves two autoimmune processes against the same cells (erythrocytes) in the same patient. One explanation for this constellation would be a postinfection cold agglutination in a patient with chronic CA disease.
Copyright © 2000 S. Karger GmbH, Freiburg
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| AAAAA
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Anti-I may be associated with pt with mycoplasma pnemonia infection
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| AAAAA
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LABORATORY TESTS USED IN THE DIAGNOSIS OF LUPUS ... thyroid disease, liver disease, infectious mononucleosis, and other chronic infectious ... ANA titers go up and down during the course of the disease, ...
www.saclupus.org/Lupus%20Pamphlets/ LABORATORY%20TESTS%20USED%20IN%20THE%20DIAGNOSIS%20OF%20LUPUS.htm - 15k - Cached - Similar pages
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| AAAAA
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The answer is 4
Infectious mononucleosis is NOT associated with anti-I
ANA is a very non-speciifc antibodies and can be associated with monnucleosis.
Anti-I is associated with mycoplasma pnemonia
Thank you very much. I hope I can help !
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| guayoman
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From the mother load of knoledge (Mrs Harrison):
The heterophile test is used for the diagnosis of IM in children and adults. Heterophile antibody is an IgM antibody that does not bind EBV proteins. In the test for this antibody, human serum is absorbed with guinea pig kidney, and the heterophile titer is defined as the greatest serum dilution that agglutinates sheep, horse, or cow erythrocytes. Tests for heterophile antibodies are positive in 40% of patients with IM during the first week of illness and in 80 to 90% during the third week. Therefore, repeated testing may be necessary, especially if the initial test is performed early.
EBV-specific antibody testing is used for patients with suspected acute EBV infection who lack heterophile antibodies and for patients with atypical infections.Serologic tests are particularly useful in young children, who often do not develop heterophile antibodies.
Antibodies to early antigens (EAs) are found either in a diffuse pattern in the nucleus and cytoplasm of infected cells (EA-D antibody) or restricted to the cytoplasm (EA-R antibody). These antibodies are detectable 3 to 4 weeks after the onset of symptoms in patients with IM. About 70% of individuals with IM, especially those with relatively severe disease, have EA-D antibodies during the course of their illness.
IgA antibodies to EBV antigens have proved useful for the identification of patients with nasopharyngeal carcinoma and of persons at high risk for the disease. Seroconversion to EBNA positivity is also useful for the diagnosis of acute infection with EBV
Copyright© 2001 McGraw-Hill. All rights reserved.
But no anti-I....what is it?
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| guayoman
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Thanks AAAAA
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| MDcooper
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anti nuclear antibodies is the right answer.But I am just stuck on anti-I ????what is it?
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| AAAAA
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URGENT URGENT READ THIS VERY CAREFUL
Anti-I is assosociated with the diagnosis of Mycoplasma pnemonia
Anti-i is associated with infectious mononucleaosis
I reviwed the may Clinic textbook today
Both are secondary diseases associated with COLD AGGLUTINS
Anti-I and anti-i are both cold agglutinins but they are totally different ! 
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| AAAAA
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They are the cold agglutinins
the Anti-BIG I
the Anti-little i
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| MDcooper
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hey thanx dude.
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| guayoman
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One less ignorance point for me!
THanks
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