carollyncheeyen
Forum Newbie
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Posts: 7
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I wonder if there's an expiry date for the Q's?
Case statistics from Pub Med:
Acute bradycardia and hypotension occurred following rib retraction in 3 patients given baclofen 30 mg by mouth 90 minutes before thoracic surgery under general anaesthesia, but not in a further 3 patients given placebo.Giving atropine and ephedrine relieved bradycardia and hypotension in 2 patients, but a brief cardiac arrest occurred in 1.
Baclofen may disturb autonomic control of the circulation during general anaesthesia and surgery.
Baclofen, an analogue of GABA, is a centrally acting skeletal muscle relaxant. It interferes with the release of excitatory neurotransmitters and inhibits monosynaptic and polysynaptic transmission at the spinal cord level. It may also act at supraspinal sites producing CNS depression. Baclofen is1of the drugs commonly used for the symptomatic relief of severe chronic spasticity associated with a variety of conditions.
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