mjl1717
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which one crosses the blood brain barrier ?
a)Pennicillin
b)Chlorotetracycline
c)Erythromycin
d)Pyridostigmine
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| drpkaur
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Is it B ??? ..as i have read that penicillin do not enter CNS unless meninges are inflamed ...as pyridostigmine is a quarternary amine therefore no CNS entry for erythromycin i haven't read anywhere that it crosses BBB...correct me if i am wrong...
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| Slacker
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C. Erythromycin because it is tetrogenic. Anything that is tetrogenic can cross the BBB.
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| mjl1717
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actually I thought it was answer b also, but its --Erythromycin. good deductive reasoning guys. 
(dont know about you guys but Im not seeing any icons on this new laptop.
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| tolito
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good job guys.
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| HILFIGER
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Good question
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| drpkaur
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hey tolito ,could you plz check about erythromycin on page 374 in lippincott's 3rd edition as it is written that Erythromycin distributes well to all body fluids except the CSF(BBB).moreover a picture is also given on the same page indicating that erythro,azithro and clarithromycin does not penetrate into CNS....guys plz clear it ....
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| tolito
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well, i did check lippincott and it says ' erythromycin distributes well to all body fluids except CSF'.
however, checking online, i got this link that says in the last line that erythromycin does cross better than penicillin and tetracycline
http://www.thamburaj.com/bloodbrain.htm
we are all agreed that pyridostigmine does not cross. so best answer remains erythromycin.
about erythromycin being teratogenic, tetracycline too crosses placenta and spoils baby's teeth!!!
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| mjl1717
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good referencing guys!! I got this particular q from "exam master" who for some reason ive always been a little skeptical of. .
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| robin082006
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guys, I'm skeptical about the correct answer. I learned that tetracycline groups can go across placenta and blood brain barrier when I was a student and a representative of a pharmaceutical company.
About Ery, its ability going across BBB is limited but this increases when meninges are inflamed.
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| pocas
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not a good question
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| tolito
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agree. not a good question
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