 |  steroids and WBC, RBC,and,,,,
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| Author | 9 Posts |
amer_almohssen
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Hey guys,
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Can Any one please please please, give me the mechanism of action of the effect of the glucocorticosteroid effects on the body cells, ESPECIALLY THE WBC ( and T-cells ), RBCs, and the the platelets.
Is there any effect by the steroids on the adhesion molecules, and t-cell receptors ?!?!?
Thank you so very much in Advance
amer
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| drpkaur
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hi
what i have read from my textbook is that glucocorticoids causes lymphocytopenia,monocytopenia,eosinophilopenia....moreover they inhibit proliferation of T-lymphocytes....platelets increase in number....you can also check in your textbook to correct me if i am wrong...hope it helps...
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| tolito
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steroids inhibit chemotaxis. i do not know the mechanism for that. maybe inhibit release of cytokiones from memb stabilisation????. no info on tcr. will look that up.
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| mjl1717
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my q is what is the mech. of action of steroids both at the pharmaceuticial level and at the molecular level. perhaps we can do a collective project: For starters:
1)they belong to a superfamily of nuclear receptors called "ligand-activated transcription factors"
2)the steroid hormone receptor has a nuclear localization that allow it to reside in the nucleus
3)"heat shock protein is a key word associated with steroid hormon.
all are welcome to add info!
Edited by mjl1717 on 05/31/06 - 02:34 PM
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| Slacker
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corticosteroids cause inhibition of Phospholipase A2. Thus LTB4 is not made. LTB4 has 2 functions: 1. activate neutrophil adhesion molecules. 2. cause chemotaxis of neutophils. Thus if corticosteroids are given---->decreased activation of neutrophils adhesion molecules---->increased levels of neutrophils in the blood.
Corticosteroids sequester eosinophils in the lymph nodes---->decreased eosinophils in the blood. Thats why they are used for type I hypersensitivity.
Corticosteroids also decrease blood levels of T and B cells but i dont know the mechanism of that
Hope this helps
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| amer_almohssen
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thaks a lot man, this really helps a lot
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| tolito
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good job slacker, mjl1717
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| tolito
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corticosteroids cause absolute lyhmphopenia by increasing lymphocyte adhesion in the lymph nodes. they also have a lymphocytotoxic effect.
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| mjl1717
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Roids in simple words: also activate gene transcription.
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