nadiabarati
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6. A 4 year old girl is brought to the emergency department because of the 5 day history of fever, diffuse abdominal pain, nausea, vomiting, and diarrhea. Examination shows petechiae, hepatomegaly, and splenomegaly. Hemoglobin concentration is 8.7 g/dL and platelet count is 60,000/mm3. A peripheral blood smear shows erythrocyte fragmentation. which of the following renal findings is most likely to be associated with their condition? a) glomerular crescent formation
b) IgG-associated glomerular basement membrane antibody
c) Membranoproliferative glomerulonephritis
d) narrowing of the capillary wall by fibrin deposition
e) periglomerular granuloma with giant cells
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| doc179
Forum Guru
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Posts: 1,217
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is it HUS? A ?
Edited by doc179 on 05/19/06 - 03:12 PM
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| sridevibandaru24
Forum Guru
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D?
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| babli
Forum Guru
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A.....HUS
The light microscopic findings of the first renal biopsy performed before treatment revealed extensive interstitial changes with remarkable mononuclear cell infiltrations as well as mild mesangial proliferation with crescent formation.
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| ladybug
Forum Senior
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Posts: 57
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On histologic examination in the kidney of patients with HUS, changes in glomeruli vary from minimal to severe with abnormalities such as endothelial edema, degeneration of endothelium, thickening of capillary walls, thrombi and fragmented RBCs. histologic abnormalities may occur in only some glomeruli. In patients with persistent renal abnormalities years after HUS, biopsy may show glomerulosclerosis.
SOurce: Moghal NE. The late histologic findings in diarrhea-associated hemolytic uremic syndrome. J Pediatr 1998; 133(2):220-3.
Microvascular damages occur with arterioles and small arteries occluded by eosinophilic hyaline thrombi containing fibrin and platelet aggregates. Hence, narrowing of the capillary walls.
Answer is D.
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| guangyu
Forum Elite
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Posts: 308
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so what is the answer?
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| Cedrick
Forum Fanatic
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D
minimal change ?
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| Cedrick
Forum Fanatic
Topics: 322
Posts: 1,990
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Still D
But Dx TTP
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| robin082006
Forum Hero
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D for sure
a) glomerular crescent formation : rapidly progressive glomerulonephritis,
b) IgG-associated glomerular basement membrane antibody: Good Pasture's
c) Membranoproliferative glomerulonephritis
d) narrowing of the capillary wall by fibrin deposition: HUS
e) periglomerular granuloma with giant cells: renal amyloidosis
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| disha
Forum Senior
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Posts: 118
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erythrocytic fragmentation is also seen in microciitic polyangiitis?
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