leen
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Twenty four hours after placement of a catheter, a hospitalized patient develops a fever and chills. Within 1 hour her systolic blood pressure falls 30 points and she develops swelling in her extremities. Despite valiant efforts by the hosipital staff, the patient dies. X-ray of the patient's lungs taken only hours before she passed away shows pulmonary edema. Which of the following mediators of this patient's disease process is most likely responsible for the pathology depicted?
A. C3a
B. C5a
C. Hageman factor
D. Interleukin-1
E Nitric Oxide
F. Tumor necrosis factor
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| robin082006
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I read somewhere TNF, IL1, TGF beta are related to acute pulmonary edema. Here are two confused choices D and F but I go with F
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| doc179
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B ? not sure..
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| summer
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This is a nice qx for reviewing many things. I hope i don't get something like this in my test. this patient looks like going through a septic shock after the catheter implantation. This may lead to Acute Respiratory Distress Syn. Here, there is release of mediators and cytokines, such as TNF alpha and IL-1, which can be the first ones to start the reaction that will end up with multiple organ dysfunction synd. I would go with IL-1 which is very associated with septic states, but ... pls answer it!!
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| ralux
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a
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| leen
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I found this q on some forum the person who posted the q says that the given ans is a
my q is if a could b the right choice then why not B?
pl advice
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| doc179
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dont know why..
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| general malaise
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wierd q, obviously person had ARDS secondary to septic shock, in which IL-1 and TNF are the main mediators. i wouldn't have thought complement factors are more important than interleukins in pathophys of shock
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| tolito
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quite a weird question. all the mediators above are involved in septic shock but not all of them cause fever + hypotension. only TNF alpha does that. the activated macrophage produces il1, tnf, nitric oxide, il1 will give fever no hypotension, no will cause hypotension no fever.
the activated complement , c3a will cause hypotension and edema, no fever, c5a will cause more neutrophil chemotaxis. activated hageman factor will cause DIC.
i wil still go with F if i had to choose the single best option.
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| ts97
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Why "swelling in her extremities"? At first I thought about latex allergy.
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| ts97
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F: "TNF secreted by activated macrophages can cause blood vessels to become leaky"...
"How the Imunne System Works" by Lauren Sompayrac.
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| 26malik
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very wierd Q. i will go for F too.
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