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NBME Form 1 - Alveolar Repair
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Author30 Posts
  #26

Type I main job is to facilitate alveolar gas exchange.
Type II main job is to secrete surfactant AND differentiation into type I pneumocytes if type I gets damaged.

Answer is type 2 pneumocytes, choice E).

  #27

true it is typeII cells
(FA)HISTOLOGY

  #28

E) Type II pneumocytes

  #29

It is Type II Pneumocytes. Clara cells cover the Bronchial Epithelium. Endothelial cells have no alveolar function. Type I Pneumocytes are the alveolar lining but cannot regenerate. When there is alveolar damage, such as in this question stem, type 2 pneumocytes cover the injury and begin to differentiate into type I pneumocytes. The clue is in the REGENERATION. Only one up there that regenerates in the alveolar space is type II pneumocytes. In addition, just for fun, 95% of the alveolar lining is type I pneumocytes, but yet type 2 seem to do most of the work!!! smiling face I hope this clarifies it for some of you! Thanks

Ross University Graduate
Massachusetts General Hospital
Harvard

___________________
Elite

  #30

answer E junkeira:Type II cells are rounded cells that are usually found in groups of two or three along the alveolar surface at points at which the alveolar walls unite and form angles. These cells, which rest on the basement membrane, are part of the epithelium, with the same origin as the type I cells that line the alveolar walls. They divide by mitosis to replace their own population and also the type I population. In histological sections, they exhibit a characteristic vesicular or foamy cytoplasm


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