NBME Form 1 - Alveolar Repair

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NBME Form 1 - Alveolar Repair

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humpf!!
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05/15/06 - 11:54 AM

A 40 year old man is brought to the emergency department after being exposed to ozone and nitrogen dioxide at a factory. He dies shortly thereafter. At autopsy, examination of tissue taken from a lung biopsy suggests damage to his alveolar epithelium. If he had survived, this layer would have likely been regenerated within several weeks by which of the following cells?

A) Clara cells

B) Endothelial cells

C) Reticular cells

D) Type I pneumocytes

E) Type II pneumocytes

vanshita
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05/16/06 - 07:37 PM

robin082006
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05/16/06 - 07:45 PM

B

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mdx
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05/17/06 - 01:50 PM

D ?!

humpf!!
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05/17/06 - 01:52 PM

i think it's D

mjl1717
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05/17/06 - 04:10 PM

as far as I know type I -repair////////////type II surfactant

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robin082006
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05/17/06 - 09:10 PM

type I does not replicate,

just search by Google, you will se epithelial cells are responsible for repairing alveolar damage.

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tolito
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05/19/06 - 05:36 PM

type 1 does not replicate but type II is responsible for alvelar epithelial repair following injury.

http://www.blackwell-synergy.com/doi/pdf/10.1111/...

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mjl1717
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05/22/06 - 01:57 AM

ok I just blew that.

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humpf!!
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05/22/06 - 04:45 AM

#10

mjl171 - me toooo!!!! i don't know where i must have read it, but i had picked D as well...

robin082006
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05/22/06 - 08:16 AM

#11

Type II is the cells that produce Surfactant.

There are lots of scholarly articles writing about alveolar repair of epithelial cells.

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Flying h4x0r
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05/24/06 - 11:00 PM

#12

E

Robbins 7th edition, page 713.

mjl1717
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05/25/06 - 12:45 AM

#13

i know type II secrete surfactant using the lecithin and phosphatydl choline molecule.

can someone concretely say the answer to this 1 step question and define a couple of the distractors.

for some reason I cant get to the link.

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rebmd
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05/29/06 - 02:43 PM

#14

the answer is E, type II pneumocytes secrete surfactant, and can undergo mitotic activity to repair the lung.

not sure why some of you picked endothelial cells and then insisted that was the answer.

i would be interested to "read" the many scholarly articles out there on endothelial cells and regeneration of damaged lung tissue.

mjl1717
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05/29/06 - 07:29 PM

#15

yes, I also heard that the answer is type II pneumocytes. the scholarly articles?-thats for another day.

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rebmd
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05/29/06 - 08:20 PM

#16

mjl1717 wrote:
yes, I also heard that the answer is type II pneumocytes. the scholarly articles?-thats for another day.

i was kidding about the scholarly articles. there aren't any that exist b/c that is not the function of an endothelial cell.

netlover
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05/30/06 - 04:55 AM

#17

It's E

spjokes
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06/05/06 - 06:38 AM

#18

I think he has died of ARDS. The formation of hyaline membrane needs time. ARDS is pathologically called as Diffuse alveolar damage.
I thought that this picture would help
http://medlib.med.utah.edu/WebPath/LUNGHTML/LUNG1...
I think the answer is E

study_ing
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06/05/06 - 06:37 PM

#19

thanks sp jokes
can we please have some rules for answering questions
if u guess put a ? or say so
if u know its the answer put the letter down
if u wrote it after just researcing it or are copying it from a source in front of u put answer definitely
i hope i do not offend anyone but this wud really help coz its the way i answer questions when i try to do them for learning (rather than judging my performance...that i'll do in a proper test later)

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general malaise
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06/05/06 - 07:13 PM

#20

answer is E, type II pneumocytes have mitotic capacity and replace both type I and II

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nadiabarati

06/15/06 - 06:54 PM

#21

general malaise is right

Cedrick
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06/26/06 - 01:35 PM

#22

Go tolito

E

waqastariq

06/29/06 - 09:45 AM

#23

type II cells act like stem cells..
they are 3% of all the cells but they regenerate.. smiling face

waqastariq

06/29/06 - 09:45 AM

#24

option E

MHP
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07/04/06 - 08:15 PM

#25

the answer is in FA page 409. 2006

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