NBME Form 1 - Ganlion Blocker

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NBME Form 1 - Ganlion Blocker

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humpf!!
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05/14/06 - 10:18 AM

A 23 y.o. woman is scheduled to undergo surgical repair of an aortic malformation. A ganglionic blocking agent is administered before the procedure to decrease her blood pressure. The hypotension is achieved by binding of the drug at which of the following receptors?

a) alpha-1
b) alpha-2
c) beta-1
d) beta-2
e) muscarinic
f) nicotinic

drpkaur
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05/14/06 - 10:32 AM

Nicotinic

yasmeen
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05/14/06 - 10:58 AM

nicotinic

robin082006
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05/14/06 - 12:29 PM

Hexomethonium, Mecamylamine

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mjl1717
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05/15/06 - 04:44 PM

& trimethaphan (sorry this was taken off market)

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eaguin
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07/31/06 - 02:10 PM

thanks guys I did it wrong on the test... I didn't see it.

young_doc
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08/01/06 - 12:25 PM

i didn't know Nicotinics are still clinically used? More 'theoretic drugs' if anything. Especially pre-surgery, with all the side-effects...???

I think the answer is alpha-2...agonizing alpha-2 is also considered as ganglion-block. (cuz a-2 is located on pre-synaptic terminal, hence agonizing makes for decreased NT release...). So drugs like Methyldopa..etc.

Just my guess. I understand why it could be Nicotinic, but can anyone tell me why it's NOT alpha-2?

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eaguin
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08/01/06 - 05:45 PM

young_doc, nicotinic is the right RECEPTOR for a ganglionic blocking agent. Check that on the first aid page 298 2005 edition...

mjl1717
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08/01/06 - 06:22 PM

i know that ganglionic blockers work at nicotinic receptors of both parasympathetic and sympathetic ganglia. Ill return.

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docarchana
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09/24/06 - 08:07 AM

#10

nicotinic receptors are at ganglion and at NMJ

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