LisaM
Forum Guru
Topics: 16
Posts: 321
|
What is the initial management of a patient with prostate cancer and osteoblastic metastasis to bone?
Diethylsilbesterol
Radiation
Flutamide
Leuprolide
Leuprolide and Flutamide
___________________
lisa
|
| an
Forum Guru
Topics: 19
Posts: 437
|
leuprolide and flutamide?
___________________
I don't believe in miracles...I rely on them. And sometimes, I create my own.
|
| hitensoni
Forum Newbie
Topics: 0
Posts: 4
|
sorry for intruding. I am new here. I just registered. How can I post a new thread?
|
| cyra
Moderator
Topics: 29
Posts: 844
|
hitensoni,Welcome!When you want to start a new topic/thread you have to be at the main page of a forum/subforum...you'll see the option of "post new topic" at the top of the page...click on that and follow along.
|
| cyra
Moderator
Topics: 29
Posts: 844
|
Oh and I'd say leuprolide.There has been no proof of an added advantage of using leuprolide and flutamide.
|
| LisaM
Forum Guru
Topics: 16
Posts: 321
|
An is right on this one though I have probably not phrased the question right.
Leuprolide binds to LHRH receptors in anterior pituitary and causes initial increase of LH and FSH leading to a transient increase of testosterone levels. After one week of continuous therapy, there is downregulation of receptors, a decrease in LH, FSH and testosterone. Symptoms may worsen during the first week of therapy due to testosterone surge and therefore, monotherapy with Leuprolide is contraindicated in patients with vertebral metastasis or ureteral obstruction. Flutamide should be used for a week prior to starting treatment with Leurpolide in these patients.
___________________
lisa
|
| AAAAA
Forum Fanatic
Topics: 153
Posts: 1,983
|
Flutamide is also correct (in real world, we do start patients on Flutamide alone). There are really many, many modalities to treat metatstatic cancer.
I agree hormonal manipulation is the correct choice but
Flutamide and Leuroprolide should be used.
A new LHRH agonist can also be used nowaday.
___________________
seeking study partner in USMLE examination
|
| msyamp
Forum Fanatic
Topics: 60
Posts: 1,462
|
Flare with LHRH agonists is more common in this group of patients; therefore, pretreatment with antiandrogens is necessary.
___________________
If you think you can You can! If you think you cant you are right again!!
|
| AAAAA
Forum Fanatic
Topics: 153
Posts: 1,983
|
Flutamide
___________________
seeking study partner in USMLE examination
|
| AAAAA
Forum Fanatic
Topics: 153
Posts: 1,983
|
docetaxel has emerged as first-line therapy on an every-3-week schedule for metastatic HRPC, replacing mitoxantrone, as recently reported in the TAX327 trial. Docetaxel and estramustine combinations have the disadvantage of significant cardiovascular and gastrointestinal toxicity, and further use of estramustine is likely unwarranted as first-line therapy. Future trials examining novel biologic agents and combination therapies should use single-agent docetaxel as the reference standard. The role of chemotherapy for advanced disease in the neoadjuvant or adjuvant setting, in biochemically (PSA) relapsed patients, and as second-line therapy for relapsed disease, remains a subject of active clinical investigation.
___________________
seeking study partner in USMLE examination
|
| AAAAA
Forum Fanatic
Topics: 153
Posts: 1,983
|
Doxetaxel is the correct answer in 2006 too. there are just too many different therapies !
___________________
seeking study partner in USMLE examination
|
|
| |
| | | | | | | | | | | |
