amer_almohssen
Forum Junior
Topics: 13
Posts: 38
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hi
can some one please help me find the mechanizm of action of OKT3 & Antilymphocyte Globulin, and their effect on the T-cells?
Thank you
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| Slacker
Forum Elite
Topics: 29
Posts: 141
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OKT3 acts by blocking the function of T cells which play a major role in acute graft rejection. OKT3 reacts with and blocks the function of a molecule called CD3 in the membrane of T cell. The binding of OKT3 to T lymphocyte results in their early activation, which leads to cytokine release, followed by blocking T cell functions....had to look it up
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