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Author6 Posts
  #1

63 year old woman with 5 year history of type 2 diabetes,comes to physician for routine examination.she notes that her glucose concentration has been persistently higher over past 4 month since she gained 9 kg during holidays.her diabetes has been more difficult to controll because wight gain causes which of following to occur?
a.down regulation of insulin receptor
b.increased activity of hepatic glucokinase
c.increased expression of GLUT4 transporters
d.inhibition of insulin release
e.upregulation of insulin signaling
is it a?

  #2

agree, A

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  #3

nod

  #4

A is the correct answer.

  #5

yes! A is correct

  #6

ok obesity increases Resistance to insulin predisposing to DM 2.
but what is the mechanism for downregulation of insulin R?


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