NBME Inflammation

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NBME Inflammation

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DrVirgo
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05/09/06 - 11:07 AM

29.

A new analgesic drug that will decrease pain at sites of acute inflammation is to be developed. This action can be achieved by creating an antagonist to which of the following inflammatory mediators?

A

)

Bradykinin

B

)

C5a

C

)

Histamine

D

)

Interleukin-2 (IL-2)

E

)

Prostacyclin

F

)

Transforming growth factor

I think its A) Bradykinin because first of all because its a mediator of pain and also involved in the acute inflammation and injury.
Distractor: I think Prostacyclin is also a mediator of pain, but involved in the late reaction since it has to be synthesized from AA, and that will take time.

Any ideas?

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yasmeen
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05/09/06 - 11:23 AM

BRADYKININ IS POTENT MEDIATOR OF PAIN

robin082006
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05/09/06 - 11:57 AM

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DrVirgo
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05/09/06 - 08:47 PM

Is Histamine also a mediator of pain?

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mjl1717
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05/10/06 - 09:41 PM

histamine is known for wheal and flare rxn, lacrimation and rhinorrhea.

dynorphin, endorphin and enkephalin could be mediators of pain.

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dariush
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05/11/06 - 03:58 AM

mjl1717 wrote:
histamine is known for wheal and flare rxn, lacrimation and rhinorrhea.

dynorphin, endorphin and enkephalin could be mediators of pain.

dynorphin, endorphin and enkephalin are Moderators of pain (endogenous opioids) not mediators.

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vamsi2004
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08/07/06 - 08:25 PM

PGE2 is a mediator of pain, not prostacyclin (PGI2)

pocas
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08/08/06 - 08:44 AM

BRADYKININ

docarchana
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09/23/06 - 07:22 PM

bradykinin and PGE2 are mediators of pain

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