DrVirgo
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39.
A clone of cancer cells is resistant to vincristine, doxorubicin, and dactinomycin but not to methotrexate and various alkylating agents. The mechanism of resistance is most likely to involve
A ) Absence of superoxide dismutase
B ) Altered DNA polymerase
C ) Enhanced drug transport out of the cell
D ) Inability to form polyglutamates
E ) Increased DNase
I guess C.... But can anyone explain for sure???
THanks. 
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| robin082006
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C, has been discussed
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| Cedrick
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yes it has been discussed.- C
but I looked it up anyway for me
Resistant cells have shown to have enhanced to P-glycoprotein,which is resposible for the efflux of vincristine,vinblastine and several other drugs.
page 390 Chapter 38 anticancer drugs
Lippincott's pharmacology 2nd edition
Thnaks to all here
my preparation is WAY more guided
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| DrVirgo
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Thanks for the explanation cedrick. -highly appreciated.
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| Musuq
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thanks man!
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