DrVirgo
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19.
A 23-year-old woman with a history of asthma comes to the physician's office because she has had progressive wheezing over the past 2 days. Which of the following drugs is most likely to induce bronchodilation in this patient by activation of adenylyl cyclase?
A
)
Albuterol
B
)
Beclomethasone dipropionate
C
)
Cromolyn sodium
D
)
Ipratropium bromide
E
)
Theophylline
Everyone agree with A? 
What are the mechanisms of the other drugs?
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| yasmeen
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 A
B ANTI INFLAMATORY
C MAST CELL STABILIZER
D ANTI CHOLINERGIC
E PHOSPHODIESTERASE INHIBITOR
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| DrVirgo
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Thanks.
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| robin082006
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| mjl1717
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Good yasmeen!
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| Cedrick
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Asthma.-Albuterol
Choice A
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| eaguin
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a
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| giovanni83
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but maybe also theophillyn cause enhances of cAMP....
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| drsnq
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giovanni83
in this q ask about the drug which increase adenylate cyclase which is albuterol (beta agonist
theophyline dec cAMP by inhibiting phosphodiestrase enzyme thats why dec Amp not inc
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| docswapna
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beta agonists stimulate adenyl cyclase
theophylline inhibits phosphodiesterase
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| qumsieh
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Okay, reading some of your posts is giving me a stomach ache just thinking about you being physicians! I don't mean to offend anyone just how I feel! As for the reply from drsnq, please disregard his answer, theophylline does NOT decrease cAMP, that is NOT true. Theophylline inhibits PDA (phosphodiesterase--which breaks down cAMP) as does caffiene. Please do NOT post answers that are WRONG or Misleading as some people may become confused or actually remember YOUR WRONG answer while taking an exam! Be 100% certain PLEASE for all our sakes and your patients sake most of all!!!! Now to Answer the question. The answer is A) Albuterol (Beta agonists which act sympathomimetically to increase adenylate cyclase via Gs subunit) B) is a steriod C) decreases mast cell degranulation D) Is an Anti-muscarinic drug which acts via Gq subunit on M3 receptor. Similar to atropine. E) Theophylline is a PDE inhibitor which increases cAMP which will actually decrease adenylate cylase via feedback inhibition! Hope this helps.
Ross University Graduate
Massachusetts General Hospital
Harvard
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| vaibhavbora
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