NBME Tamoxifen

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NBME Tamoxifen

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DrVirgo
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05/09/06 - 10:09 AM

3. A 68-year-old woman has breast cancer that is metastatic to the axillary lymph nodes. The primary tumor is excised and chemotherapy, including cyclophosphamide and tamoxifen, is started. Which of the following mechanisms best explains the likely beneficial effect of tamoxifen in this patient?

A) Competition with cytoplasmic estrogen receptors

B) Enhancement of cyclophosphamide cytotoxic effect therapy

C) Inhibition of residual estrogen synthesis by the ovaries and adrenal glands

D) Retardation of tumor growth by its androgenic activity

E) Stimulation of membrane-bound progestin receptors

Everyone agree with A?

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yasmeen
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05/09/06 - 11:07 AM

robin082006
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05/09/06 - 12:00 PM

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drpkaur
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05/09/06 - 07:58 PM

Cedrick
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06/26/06 - 09:48 PM

Yes.-A

Part of the selective estrogen receptor modulators

pocas
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06/26/06 - 11:01 PM

disha
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06/28/06 - 02:04 PM

ya its a

tamoxifen is-antagonist on breast,partial antagonist on uterus n agonist on bone

am i right?

pocas
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06/28/06 - 11:14 PM

breast antagonist , partial agonist FOR ENDOMETRIUM .

receptor agonist for bone

DrVirgo
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07/05/06 - 08:28 AM

agree with A. smiling face

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waqastariq

07/05/06 - 08:29 AM

#10

MHP
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07/05/06 - 11:20 AM

#11

docswapna
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09/24/06 - 11:52 AM

#12

pocas wrote:
breast antagonist , partial agonist FOR ENDOMETRIUM .

receptor agonist for bone

dunno this b4. thanku

lightray
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09/29/06 - 02:10 AM

#13

As Tamoxifen is partial agonist for endometrium...possible increased risk of endometrial cancer...hence when SERMs are to be used in menopausal women RALOXIFEN is preferred as it is E-receptor agonist for bone....and antagonist for both breast and endometrium

docsrinu
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09/29/06 - 06:38 AM

#14

good point..

thanku.

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