khorshid
Forum Guru
Topics: 32
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I don't understand something in anerobic glycolysis. It says that we gain 2 ATP/ Glucose( one from the action of phosphoglycerate kinae and the other from pyruvate kinase) but to me that's not true, because we have used 2ATPs before( one for the hexokinase and one for PFK-1).so it seems that we're using two and getting two back, which means nothing and that doesn't sound right...does anyone know what's going on?
my second question is that where do we get two NADHs during aerobic glycolysis? One I know is in Glyceraldehyde 3P Dehydrogenase action, but what about the second one? it can't be the lactate dehydrogenase, because that's for the anerobic pathway...So?
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| Bartek
Forum Senior
Topics: 1
Posts: 64
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I would simply double your ATP and NADH gain count:
1- we use 2 ATPs, but we gain 2 ATPs from phosphoglycerate kinase AND next 2 ATPs from pyruvate kinase, so total gain is 4 ATPs and total result -2 + 4 = 2
2 - I think that for glyceraldehyde phosphate dehydrogenase action 2 NAD+s are used
reference:
http://www.biocarta.com/pathfiles/h_glycolysisPat...
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| khorshid
Forum Guru
Topics: 32
Posts: 591
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Thanks Bartek! Now it's clear, in kaplan notes it doesn't mention that quantity
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| star1
Forum Guru
Topics: 93
Posts: 826
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cAN ANYBODy explain how glycolysis make 36ATP in aerobic and how much in anaerobic ? I just forget it and cant do it myself plz any body write especially doc179
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| khorshid
Forum Guru
Topics: 32
Posts: 591
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Aerobic glycolysis:36-38 ATPs (including TCA cycle): aerobic glycolysis itself gives 2 ATPs and 2 NADHs, which depending on wether it goes through Malate shuttle or Glycerol phosphate shuttle will give 4 or 6 ATPs respectively, there fore makes the total 6 or 8.
In TCA cycle:
pyruvate to acetyl CoA: NADH
Isocitrate to alpha ketoglutarate: NADH
alpha ketoglutarate to Succinyl CoA:NADH
Malate to OAA: NADH
Succinate to Fumarate :FADH2
Succinyl CoA to Succinate :GTP
each NADH=3ATP, each FADH2=2ATP,
and we have 2 pyruvates from each glucose
SO: 8NADH+2FADH2+2ATP( actually GTP)= 30 ATP
30 from TCA + 6 0r 8 from glycolysis = 36 or 38
Hope this helps
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