doc179
Forum Guru
Topics: 67
Posts: 1,217
|
B?
|
| general malaise
Forum Guru
Topics: 14
Posts: 433
|
A?
___________________
"El respeto al derecho ajeno es la paz" Benito Juarez
|
| sridevibandaru24
Forum Guru
Topics: 33
Posts: 434
|
B?
|
| robin082006
Forum Hero
Topics: 471
Posts: 5,123
|
B
___________________
The Key to Succeed is Patience.
|
| yasmeen
Forum Guru
Topics: 71
Posts: 947
|
B
|
| vallia
Forum Guru
Topics: 98
Posts: 889
|
it was E, and the given explanation is this
The correct answer is E. What links rheumatoid arthritis (RA) to restrictive cardiomyopathy? Amyloid! Long-standing inflammatory conditions such as RA are associated with deposition of a form of amyloid known as AA (amyloid-associated protein), which may involve kidneys, heart, liver, skeletal muscle, and skin, for example. Amyloid deposition in the myocardium results in decreased compliance and impaired diastolic filling, i.e., restrictive cardiomyopathy. The myocardium has a rigid and waxy texture. This form of amyloid, as well as any other biochemical form, can be visualized on tissue section by staining with Congo red, which acquires a characteristic apple-green birefringence under polarized light.
Constrictive pericarditis (choice A) is due to any pathologic process that results in fibrous thickening of the pericardium, with resultant impaired compliance. Clinically, therefore, this condition manifests with a picture similar to restrictive cardiomyopathy because of impaired diastolic filling. Constrictive pericarditis is usually caused by previous episodes of acute pericarditis, especially hemorrhagic, suppurative, and caseous pericarditis.
Dilated cardiomyopathy (choice B) is characterized by massive ventricular dilatation and may be caused by genetic alterations, myocarditis, toxic insults (alcohol), metabolic disorders (hemochromatosis), etc. Most cases are idiopathic. The main pathophysiologic alteration is impaired contractility.
You may be tempted to think that this patient is prone to developing hypersensitivity myocarditis (choice C), but this form of myocardial disease has been reported after treatment with some antihypertensive agents, antibiotics, and diuretics -- not with corticosteroids or NSAIDs. Furthermore, myocarditis manifests acutely with arrhythmias and heart failure, and chronically with dilated
___________________
fight possessed
|
| proctalgia
Forum Senior
Topics: 2
Posts: 209
|
I was confused bit at first because i was thinking in the line of side effects of drugs in the clinical setting.anyway ur explanation seems ok. It is a good one
|
| proctalgia
Forum Senior
Topics: 2
Posts: 209
|
A 50-year-old woman with a history of unstable angina suffers an acute myocardial infarction. Thrombolytic therapy with tissue plasminogen activator (tPA) is administered to restore coronary blood flow early in the course of this myocardial infarction. In spite of this therapy, the degree of myocardial fiber injury may increase because of which of the following cellular abnormalities?
A Cytoskeletal intermediate filament loss
B A decreased intracellular pH from anaerobic glycolysis
C An increase in toxic oxygen radicals
D Mitochondrial swelling
E Nuclear chromatin clumping and decreased protein synthesis
|
| usmle99
Forum Junior
Topics: 4
Posts: 49
|
C ...reperfusion injury
|
| general malaise
Forum Guru
Topics: 14
Posts: 433
|
___________________
"El respeto al derecho ajeno es la paz" Benito Juarez
|
| proctalgia
Forum Senior
Topics: 2
Posts: 209
|
toxic oxygen radicals are released from neutrophils when blood flow is restored following ischemia. perfusion injury , yes C is correct
|
|
| |
| | | | | | | | | | | |
