Medusin
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I have a question for you guys. How does hypo/hyperthyroidism cause amenorrhea?
What is the pathophysiology?
Thanks.
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| Medusin
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I am guessing it has to do with excess prolactin release and the inhibition of gonadotropins for hyperthyroidism....is that right?
What about for hypothyroidism?
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| tolito
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hyperprolactinaemia is one way for hyperthyroidism. i searched for answers and here is what i got.
http://www.jpgmonline.com/article.asp?issn=0022-3...
Menorrhagia is reported to occur in 32-56% of cases of myxoedema. The mechanisms through which reproductive dysfunction occurs are multiple e.g. altered TRH response, altered LH response, peripheral conversion of androgens to estrogens, change in androstendione metabolism, catecholoestrogens, altered sex hormone binding globulin levels
ref="http://72.14.207.104/search?q=cache:PViwzikJu5gJ:www.cpsp.edu.pk/jcpsp/ARCHIEVE/July2005/Article1.pdf+amenorrhoea+and+hypo+or+hyperthyroidism&hl=en&gl=us&ct=clnk&cd=19]http://72.14.207.104/search?q=cache:PViwzikJu5gJ:www.cpsp.edu.pk/jcpsp/ARCHIEVE/July2005/Article1.pdf+amenorrhoea+and+hypo+or+hyperthyroidism&hl=en&gl=us&ct=clnk&cd=19
It also produces reproductive abnormalities including irregular menstrual or estrous cycle, amenorrhoea, and sterility in many species of female mammals. The adrenal dysfunction may contribute to the inhibition of luteinizing hormone releasing hormone (LHRH) secretion from hypothalamus, possibly mediated by excess corticotropin releasing hormone (CRH).
anone with more insight??
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| Medusin
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Thank you toilto.
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| Medusin
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BRS physiology says that TSH secretion hypersecretion causes prolactin to be secreted, and prolactin has an inhibitory effect on gonadotropins LH and FSH causing menstrual abnormalities such as amenorrhea.
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| tolito
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thanks medusin. that is more like USMLE stuff. simple and straight to the point.
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