DrVirgo
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7. A 10-year-old boy with asthma has been receiving oral hydrocortisone daily in increasing doses for the past 2 years. He is obese and has growth retardation and edema of his lower limbs. Which of the following is the most likely explanation for the edema?
A
) The drug binds to both glucocorticoid and mineralocorticoid receptors
B
) The drug is converted to a mineralocorticoid in the liver
C
) Pulmonary production of angiotensin is increased
D
) Renin activity is increased because of stress
E
) Secretion of ADH (vasopressin) is increased because of stress
A?
Can anyone explain the mechanism of action?
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| r_albayunen
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a?
in the fasciculata zone .. some books says that although cortisol secretion is here there can also be aldosterone secretion that is most likely supressed by dexamethasone so i need reassurance .. 
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| yasmeen
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A IS RIGHT
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| robin082006
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| DrVirgo
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I thought A also...
Since: The drug binds to both glucocorticoid and mineralocorticoid receptors,
--- this causes release of aldosterone and reab. of Na and H2O?
Is that right?
Thanks. 
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| rman
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yes, correct. cortisol has both glucocorticoid and mineralcorticoid effects. Dexamethasone, a steroid with a much longer half life has a potent glucocorticoid effect but no mineralcorticoid effect.
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| HILFIGER
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Agree, generally glucocorticoides also exert to some extent mineralocortiocied actions
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| drpkaur
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Yes i also Agree, generally glucocorticoids also exert to some extent mineralocortiocoid .. actions
so it would be A..
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| shalini.ravi
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