DrVirgo
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42. A 62-year-old man develops numerous superficial blisters over the scalp, face, groin, and trunk. New lesions develop over areas subjected to minimal trauma. Biopsy of one of the lesions shows an intraepidermal blister with suprabasal acantholysis. Serologic studies are likely to show an autoantibody directed against which of the following?
A) Anchoring filaments
B) Basement membrane proteins
C) Desmosomal proteins
D) Hemidesmosomal proteins
E) Integrins
Answer: C?
Pemphigus?
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| yasmeen
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PEMPHIGUS VULGARIS C
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| r_albayunen
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c
antibodies against antigen desmoglein
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| robin082006
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| DrVirgo
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right. agree.
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| amer_almohssen
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it is not P.Vulgaris, because there are NO oral, or mucusal lesions the Diagnosis is P.Pemphegoid, and the answer is D
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| Cedrick
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Correct diagnosis P.Pemphegoid
correct answer is
C.Desmosomal proteins
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| study_ing
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http://www.prep4usmle.com/forum/thread/9872
this was helpful btw
i think suprabasal blisters supports P vulgaris. (robbins pg 795)
if it were subepidermal blisters, then think of b pemphigoid or dermatitis herpetiformicus
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| study_ing
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so correct dx and asnwer c
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| sjain4
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Pemphigoid does not have acantholysis. PemphiGUS does have acantholysis. Answer is C.
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