drpkaur
Forum Guru
Topics: 195
Posts: 808
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clomiphene is partial estrogen agonist at pituitary,decreases feedback inhibition of estrogens on hypothalamus and pituitary.inc FSH,LH-incr OVULATION...
used to treat infertility associated with anovulatory cycles...
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| lakshya
Forum Senior
Topics: 44
Posts: 106
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Selective estrogen receptor modulators (SERMs) is a class of medication that acts on the estrogen receptor. A characteristic that distinguishes these substances from receptor agonists and antagonists is that their action is different for various tissues, thereby granting the possibility to selectively inhibit or stimulate estrogen-like action in various tissues
Pituitary gland - clomifene blocks estrogen action, leading to an increase of follicle-stimulating hormone.
Uterus - tamoxifen may increase endometrial carcinoma risk, but raloxifene does not.
Breast - all SERMs decrease breast cancer risk
Deep venous thrombosis - the risk may be elevated in all SERMs.
Bone turnover and postmenopausal osteoporosis respond favorably to SERMs.
Hot flashes are increased by all SERMs.
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