| Author | 3 Posts |
nadiabarati
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Which modification of an endogenous pharmacological active peptide would be most likely to slow the metabolism of the peptide,thus decreasing its clearence and increasing its half-life ?? a-administering the peptide with an enteric coating
b.-Decreasing the number of amino acids in the peptide
c.-Ensuring a free amino group at the N terminal
d.-Ensuring a free carboxyl group at the C terminal
e.-Substituting a D for an L amino acid
Which modification of an endogenous pharmacological active peptide would be most likely to slow the metabolism of the peptide,thus decreasing its clearence and increasing its half-life ?? a-administering the peptide with an enteric coating
b.-Decreasing the number of amino acids in the peptide
c.-Ensuring a free amino group at the N terminal
d.-Ensuring a free carboxyl group at the C terminal
e.-Substituting a D for an L amino acid
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| robin082006
Forum Hero
Topics: 471
Posts: 5,125
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Like a question for a professional biochemist
I go with E by guessing
a-administering the peptide with an enteric coating: WILL DECREASE ABSORPTION
b.-Decreasing the number of amino acids in the peptide : INCREASE RATE OF METABOLISm
c.-Ensuring a free amino group at the N terminal : DEAMINASE CAN BREAK IT
d.-Ensuring a free carboxyl group at the C terminal : DECARBOXYLASE CAN BREAK IT
e.-Substituting a D for an L amino acid : NO IDEA, THAT I CHOOSE IT
HAHAHA
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| nadiabarati
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thanks robin I think you are right
[left] [/left]
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